Alzheimer's Disease (AD) represents a major and rapidly growing burden to the healthcare
ecosystem. A growing body of evidence indicates that cognitive, behavioral, sensory, and …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

We recommend a new term,“primary age-related tauopathy”(PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads,
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Two thousand three hundred and thirty two nonselected brains from 1-to 100-year-old
individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for …

Introduction Alzheimer's disease (AD) progression follows a specific spreading pattern,
emphasizing the need to characterize those brain areas that degenerate first. The …

Background New research criteria for preclinical Alzheimer's disease have been proposed,
which include stages for cognitively normal individuals with abnormal amyloid markers …

Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …