Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Cardiac fibrosis is a substantial problem in managing multiple forms of heart disease.
Fibrosis results from an unrestrained tissue repair process orchestrated predominantly by …

Background & Aims Mechanical forces contribute to portal hypertension (PHTN) and
fibrogenesis. We investigated the mechanisms by which forces are transduced by liver …

Endogenous direct-current electric fields (dcEFs) occur in vivo in the form of epithelial
transcellular potentials or neuronal field potentials, and a variety of cells respond to dcEFs in …

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver
microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

BACKGROUND & AIMS:: The renin-angiotensin system plays an important role in hepatic
fibrogenesis. In other organs, myofibroblasts accumulated in damaged tissues generate …

Despite the important roles played by ventricular fibroblasts and myofibroblasts in the
formation and maintenance of the extracellular matrix, neither the ionic basis for membrane …

The liver is among the most frequently targeted organs by noxious chemicals of diverse
nature. Liver toxicity testing using laboratory animals not only raises serious ethical …

The importance of inflammation in initiating the sequence of events that lead to liver fibrosis
is increasingly recognized. In this study, we tested the effects of SC‐236, a selective …