There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

The respiratory epithelium provides a physical, functional, and immunologic barrier to
protect the host from the potential harming effects of inhaled environmental particles and to …

The main interfaces controlling and attempting to homeostatically balance communications
between the host and the environment are the epithelial barriers of the skin, gastrointestinal …

Environmental exposures interplay with human host factors to promote the development and
progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a …

Although oral tolerance is the normal physiologic response to ingested antigens, a
breakdown in this process appears to have occurred in the past 2 decades, leading to an …

Air pollutants include toxic particles and gases emitted in large quantities from many
different combustible materials. They also include particulate matter (PM) and ozone, and …

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …

Type 2-immunity represents the typical adaptive response to allergen exposure in atopic
individuals. It mainly involves Th2 cells and immunoglobulin E, as the main orchestrators of …

Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

Background Asthma is a chronic respiratory disease with marked clinical and
pathophysiological heterogeneity. Specific pathways are thought to be involved in the …