Early‐life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma

RR Dietert, JT Zelikoff - Birth Defects Research Part B …, 2008 - Wiley Online Library
Incidence of childhood allergic disease including asthma (AD‐A) has risen since the mid‐
20th century with much of the increase linked to changes in environment affecting the …

Evolution of pathologic T-cell subsets in patients with atopic dermatitis from infancy to adulthood

T Czarnowicki, H He, T Canter, J Han… - Journal of Allergy and …, 2020 - Elsevier
Background The circulating immune phenotype was defined in adults and young children
with early atopic dermatitis (AD), but chronologic changes in the blood of infants and …

Foals are interferon gamma-deficient at birth

CC Breathnach, T Sturgill-Wright, JL Stiltner… - Veterinary immunology …, 2006 - Elsevier
The increased vulnerability of foals to specific pathogens such as Rhodococcus equi is
believed to reflect an innate immunodeficiency, the nature of which remains poorly …

A humanized mouse model of anaphylactic peanut allergy

OT Burton, AJ Stranks, JM Tamayo… - Journal of Allergy and …, 2017 - Elsevier
Background Food allergy is a growing health problem with very limited treatment options.
Investigation of the immunologic pathways underlying allergic sensitization to foods in …

Transplant tolerance induction in newborn infants: mechanisms, advantages, and potential strategies

H Pan, A Gazarian, JM Dubernard, A Belot… - Frontiers in …, 2016 - frontiersin.org
Although several tolerance induction protocols have been successfully implemented in adult
renal transplantation, no tolerance induction approach has, as yet, been defined for solid …

A probiotic dairy product containing L. gasseri CECT5714 and L. coryniformis CECT5711 induces immunological changes in children suffering from allergy

A Martínez‐Cañavate, S Sierra… - Pediatric Allergy and …, 2009 - Wiley Online Library
The increase in the prevalence of allergic diseases in children has been attributed to an
unbalanced immune response probably due to environmental factors. The …

Phenotypic differences in leucocyte populations among healthy preterm and full‐term newborns

C Quinello, AL Silveira‐Lessa… - Scandinavian …, 2014 - Wiley Online Library
The immune system of neonates has been considered functionally immature, and due to
their high susceptibility to infections, the aim of this study was to analyse the phenotypic …

Elevation of cytokine concentrations in asphyxiated neonates

K Okazaki, A Nishida, M Kato, K Kozawa, N Uga… - Neonatology, 2006 - karger.com
Background: Various cytokines are reportedly associated with many neonatal diseases.
Asphyxia is considered to result in ischemia-reperfusion injuries and induces abnormal …

Developmental immunotoxicology (DIT): windows of vulnerability, immune dysfunction and safety assessment

RR Dietert - Journal of immunotoxicology, 2008 - Taylor & Francis
Developmental immunotoxicity (DIT) is an increasing health concern since DIT outcomes
predispose children to those diseases that have been on the rise in recent decades (eg …

Cytokine expression in response to bacterial antigens in preterm and term infant cord blood monocytes

AMF Tatad, M Nesin, J Peoples, S Cheung, H Lin… - Neonatology, 2008 - karger.com
Background: Neonatal susceptibility to bacterial infection is associated with an immature
immune system, but the role of different bacterial antigens in specific responses is largely …