Mesenchymal stem cell therapy and Alzheimer's disease: current status and future perspectives

J Kim, Y Lee, S Lee, K Kim, M Song… - Journal of Alzheimer's …, 2020 - content.iospress.com
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease
worldwide, but its cause remains unclear. Although a few drugs can provide temporary and …

Nanoparticles-based anti-aging treatment of Alzheimer's disease

JJ Chu, WB Ji, JH Zhuang, BF Gong, XH Chen… - Drug …, 2022 - Taylor & Francis
Age is the strongest risk factor for Alzheimer's disease (AD). In recent years, the relationship
between aging and AD has been widely studied, with anti-aging therapeutics as the …

Mesenchymal stem cell-derived extracellular vesicles suppresses iNOS expression and ameliorates neural impairment in Alzheimer's disease mice

SS Wang, J Jia, Z Wang - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Background: Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) have
been reported to exhibit therapeutic effects in various animal models of neurological …

Novel Development and Prospects in Pathogenesis, Diagnosis, and Therapy of Alzheimer's Disease

Z Teng - Journal of Alzheimer's Disease Reports, 2024 - content.iospress.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease with cognitive
decline and behavioral dysfunction. AD will become a global public health concern due to its …

Neural stem cells in the treatment of Alzheimer's disease: Current status, challenges, and future prospects

X Chen, S Jiang, R Wang, X Bao… - Journal of Alzheimer's …, 2023 - content.iospress.com
Abstract Alzheimer's disease (AD), a progressive dementia, is one of the world's most
dangerous and debilitating diseases. Clinical trial results of amyloid-β (Aβ) and tau …

Transplantation of GABAergic interneuron progenitor attenuates cognitive deficits of Alzheimer's disease model mice

MH Lu, XY Zhao, DE Xu, JB Chen… - Journal of …, 2020 - content.iospress.com
Excitatory (E) and inhibitory (I) balance of neural network activity is essential for normal brain
function and of particular importance to memory. Disturbance of E/I balance contributes to …

Current status and challenges of stem cell treatment for Alzheimer's disease

M Pacheco-Herrero, LO Soto-Rojas… - Journal of …, 2021 - content.iospress.com
Neurodegenerative diseases called tauopathies, such as Alzheimer's disease (AD),
frontotemporal dementia, progressive supranuclear palsy, and Parkinson's disease, among …

Neuro-immuno-gene-and genome-editing-therapy for Alzheimer's disease: are we there yet?

SP Raikwar, R Thangavel, I Dubova… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) is a highly complex neurodegenerative disorder and the current
treatment strategies are largely ineffective thereby leading to irreversible and progressive …

Mesenchymal Stem Cells for Treating Alzheimer's Disease: Cell Therapy and Chemical Reagent Pretreatment

K Zhang, X Du, Y Gao, S Liu… - Journal of Alzheimer's …, 2023 - content.iospress.com
As the size of the population aged 65 and older continues to grow, the incidence and
mortality rates of Alzheimer's disease (AD) are increasing annually. Unfortunately, current …

Ethical Aspects of Human Induced Pluripotent Stem Cells and Alzheimer's Disease: Potentials and Challenges of a Seemingly Harmless Method

M Kropf - Journal of Alzheimer's Disease Reports, 2023 - content.iospress.com
Dementia currently affects more than 55 million people worldwide, and scientists predict that
this number will continue to rise. The most common form is Alzheimer's disease (AD), which …