Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell
types holds great promise for regenerative medicine. We reported previously that cardiac …

Calcium plays a crucial role in excitation-contraction coupling (ECC), but it is also a pivotal
second messenger activating Ca2+-dependent transcription factors in a process termed …

Localized subcellular changes in Ca 2+ serve as important cellular signaling elements,
regulating processes as diverse as neuronal excitability and gene expression. Studies of …

The suppression mechanism of Tregs remains an intensely investigated topic. As our focus
has shifted toward a model centered on indirect inhibition of DCs, a universally applicable …

Rationale: CaMKII (Ca2+-Calmodulin dependent protein kinase) δC activation is implicated
in pathological progression of heart failure (HF) and CaMKIIδC transgenic mice rapidly …

Objective Pathologically increased activity of Ca 2+/calmodulin-dependent protein kinase II
(CaMKII) and the associated Ca 2+-leak from the sarcoplasmic reticulum are recognized to …

Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where
disease mutation or small molecules may alter contractility through myofilament Ca2+ …

Background—A hallmark of heart failure is impaired cytoplasmic Ca2+ handling of
cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca2+ handling …

Aims Autophagy protects against the development of cardiac hypertrophy and failure. While
aberrant Ca2+ handling promotes myocardial remodelling and contributes to contractile …