Early‐life stress confers profound and lasting risk for developing cognitive, social, emotional,
and physical health problems. The effects of stress on the developing brain contribute to this …

Childhood trauma has been associated with long term effects on prefrontal-limbic grey
matter. A literature search was conducted to identify structural magnetic resonance imaging …

Background Many studies report smaller hippocampal and amygdala volumes in
posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here …

Early adversity (EA) has been shown to be a potent risk factor for developing a
psychopathology in adulthood. Alterations of the stress system in addition to changes in …

Compelling evidence from animal and human research suggest a strong link between
inflammation and posttraumatic stress disorder (PTSD). Furthermore, recent findings support …

The early postnatal period is a highly sensitive time period for the developing brain, both in
humans and rodents. During this time window, exposure to adverse experiences can …

Early life stress in rodents is associated with increased amygdala volume in adulthood. In
humans, the amygdala develops rapidly during the first two years of life. Thus, disturbed …

This systematic review reports on moderating and mediating variables in the relationship
between childhood adversity and affective disorders. Embase, MEDLINE & PsycINFO were …

The amygdala is a core component in neurobiological models of stress and stress-related
pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have …

This study explored the degree and type of childhood trauma experienced before the age of
18 years reported by prison inmates. The Adverse Childhood Experiences (ACE) instrument …