Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Musculoskeletal disorders include rheumatoid arthritis, osteoarthritis, sarcopenia, injury,
stiffness, and bone loss. The prevalence of these conditions is frequent among elderly …

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

Background Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma that most
often develops in children. Chemoradiation therapy is a standard treatment modality; …

The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …

Background: Anterior cruciate ligament (ACL) tear (ACLT) leads to protracted quadriceps
muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to …

Satellite cells are bona fide muscle stem cells that are indispensable for successful post-
natal muscle growth and regeneration after severe injury. These cells also participate in …

A model explaining the dietary-protein-driven post-natal skeletal muscle growth and protein
turnover in the rat is updated, and the mechanisms involved are described, in this narrative …

We determined if skeletal muscle extracellular matrix (ECM) content and remodeling
markers adapted with resistance training or were associated with hypertrophic outcomes …

Skeletal muscle connective tissue (MCT) surrounds myofiber bundles to provide structural
support, produce force transduction from tendons, and regulate satellite cell differentiation …