Beyond the GFAP-astrocyte protein markers in the brain

AM Jurga, M Paleczna, J Kadluczka, KZ Kuter - Biomolecules, 2021 - mdpi.com
The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

[HTML][HTML] Behaviorally consequential astrocytic regulation of neural circuits

J Nagai, X Yu, T Papouin, E Cheong, MR Freeman… - Neuron, 2021 - cell.com
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

Z Yao, CTJ van Velthoven, M Kunst, M Zhang… - Nature, 2023 - nature.com
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

F Endo, A Kasai, JS Soto, X Yu, Z Qu, H Hashimoto… - Science, 2022 - science.org
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …

[HTML][HTML] Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use …

ML Seney, SM Kim, JR Glausier, MA Hildebrand… - Biological …, 2021 - Elsevier
Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …

Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity

W Peng, X Liu, G Ma, Z Wu, Z Wang, X Fei, M Qin… - Cell discovery, 2023 - nature.com
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is
generally thought to be involved. Here we show multiple lines of evidence supporting that …

[HTML][HTML] Region-specific transcriptional control of astrocyte function oversees local circuit activities

AYS Huang, J Woo, D Sardar, B Lozzi, NAB Huerta… - Neuron, 2020 - cell.com
Astrocytes play essential roles in brain function by supporting synaptic connectivity and
associated circuits. How these roles are regulated by transcription factors is unknown …

Diversity of reactive astrogliosis in CNS pathology: heterogeneity or plasticity?

AJ Moulson, JW Squair, RJM Franklin… - Frontiers in cellular …, 2021 - frontiersin.org
Astrocytes are essential for the development and homeostatic maintenance of the central
nervous system (CNS). They are also critical players in the CNS injury response during …

Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair

CG Hart, S Karimi‐Abdolrezaee - Journal of neuroscience …, 2021 - Wiley Online Library
Astrocytes play essential roles in development, homeostasis, injury, and repair of the central
nervous system (CNS). Their development is tightly regulated by distinct spatial and …

Astrocyte involvement in blood–brain barrier function: a critical update highlighting novel, complex, neurovascular interactions

DR Manu, M Slevin, L Barcutean, T Forro… - International Journal of …, 2023 - mdpi.com
Neurological disorders have been linked to a defective blood–brain barrier (BBB), with
dysfunctions triggered by stage-specific disease mechanisms, some of these being …