Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

Small interfering RNA (siRNA) is a potential method of gene silencing to target specific
genes. Although the US Food and Drug Administration (FDA) has approved multiple siRNA …

In the past few decades, substantial advancement has been made in nucleic acid (NA)-
based therapies. Promising treatments include mRNA, siRNA, miRNA, and anti-sense DNA …

In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great
interest in both immunotherapy and non-immunogenic applications. This surge in interest …

The successful development of nonviral delivery systems for nucleic acids has been
reported extensively over the past years. Increasingly employed to improve the delivery …

Using functional proteins for therapeutic purposes due to their high selectivity and/or
catalytic properties can enable the control of various cellular processes; however, the …

RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for
treating diverse diseases. However, their potential is commonly hindered by vulnerability to …

Chemoresistance remains a long-standing challenge after cancer treatment. Over the last
two decades, RNA interference (RNAi) has emerged as a gene therapy modality to sensitize …

Although miRNA-27a has been identified as a promising candidate for miRNA mimic
therapy of obesity, its application is limited due to enzymatic degradation and low membrane …