[HTML][HTML] Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee
S Vucic, KHS Chen, MC Kiernan, M Hallett… - Clinical …, 2023 - Elsevier
The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di
Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial …
Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial …
Chronic glutamate toxicity in neurodegenerative diseases—what is the evidence?
J Lewerenz, P Maher - Frontiers in neuroscience, 2015 - frontiersin.org
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
[HTML][HTML] Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
BJ Wainger, E Kiskinis, C Mellin, O Wiskow, SSW Han… - Cell reports, 2014 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor
nervous system. We show using multielectrode array and patch-clamp recordings that …
nervous system. We show using multielectrode array and patch-clamp recordings that …
[HTML][HTML] Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the
human motor system. In this Seminar, we summarise current concepts about the origin of the …
human motor system. In this Seminar, we summarise current concepts about the origin of the …
Corticostriatal connectivity and its role in disease
GMG Shepherd - Nature Reviews Neuroscience, 2013 - nature.com
Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …
involved in motivated behaviour. These axonal projections are formed by two distinct …
Effect of ezogabine on cortical and spinal motor neuron excitability in amyotrophic lateral sclerosis: a randomized clinical trial
BJ Wainger, EA Macklin, S Vucic, CE McIlduff… - JAMA …, 2021 - jamanetwork.com
Importance Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor …
of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor …
Controversies and priorities in amyotrophic lateral sclerosis
MR Turner, O Hardiman, M Benatar, BR Brooks… - The Lancet …, 2013 - thelancet.com
Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS)
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …
Neuromuscular junction dysfunction in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …
Modeling ALS with motor neurons derived from human induced pluripotent stem cells
Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …
Molecular and cellular mechanisms affected in ALS
L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …