The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression
Abstract N 6-Methyladenosine (m6A) is a dynamic mRNA modification which regulates
protein expression in various posttranscriptional levels. Functional studies of m6A in …
protein expression in various posttranscriptional levels. Functional studies of m6A in …
VEGF mediates commissural axon chemoattraction through its receptor Flk1
CR de Almodovar, PJ Fabre, E Knevels, C Coulon… - Neuron, 2011 - cell.com
Growing axons are guided to their targets by attractive and repulsive cues. In the developing
spinal cord, Netrin-1 and Shh guide commissural axons toward the midline. However, the …
spinal cord, Netrin-1 and Shh guide commissural axons toward the midline. However, the …
Long-range guidance of spinal commissural axons by netrin1 and sonic hedgehog from midline floor plate cells
An important model for axon pathfinding is provided by guidance of embryonic commissural
axons from dorsal spinal cord to ventral midline floor plate (FP). FP cells produce a …
axons from dorsal spinal cord to ventral midline floor plate (FP). FP cells produce a …
The ciliary protein Arl13b functions outside of the primary cilium in Shh-mediated axon guidance
Summary The small GTPase Arl13b is enriched in primary cilia and regulates Sonic
hedgehog (Shh) signaling. During neural development, Shh controls patterning and …
hedgehog (Shh) signaling. During neural development, Shh controls patterning and …
Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk
I Paredes, JR Vieira, B Shah, CF Ramunno… - Nature …, 2021 - nature.com
Neural-derived signals are crucial regulators of CNS vascularization. However, whether the
vasculature responds to these signals by means of elongating and branching or in addition …
vasculature responds to these signals by means of elongating and branching or in addition …
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of …
W Zhang, M Lei, Q Wen, D Zhang, G Qin, J Zhou… - The Journal of …, 2022 - Springer
Background The pathogenesis of chronic migraine remains unresolved. Recent studies
have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine …
have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine …
14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing
Axons must switch responsiveness to guidance cues during development for correct
pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons ventrally toward …
pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons ventrally toward …
Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control
S Schlienger, PT Yam, N Balekoglu, H Ducuing… - Science …, 2023 - science.org
Mirror movements (MM) disorder is characterized by involuntary movements on one side of
the body that mirror intentional movements on the opposite side. We performed genetic …
the body that mirror intentional movements on the opposite side. We performed genetic …
Integration of shallow gradients of Shh and Netrin-1 guides commissural axons
During nervous system development, gradients of Sonic Hedgehog (Shh) and Netrin-1
attract growth cones of commissural axons toward the floor plate of the embryonic spinal …
attract growth cones of commissural axons toward the floor plate of the embryonic spinal …
Rabies internalizes into primary peripheral neurons via clathrin coated pits and requires fusion at the cell body
S Piccinotti, SPJ Whelan - PLoS pathogens, 2016 - journals.plos.org
The single glycoprotein (G) of rabies virus (RABV) dictates all viral entry steps from receptor
engagement to membrane fusion. To study the uptake of RABV into primary neuronal cells …
engagement to membrane fusion. To study the uptake of RABV into primary neuronal cells …