JNK signaling: regulation and functions based on complex protein-protein partnerships

A Zeke, M Misheva, A Reményi… - … and Molecular Biology …, 2016 - Am Soc Microbiol
The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Mechanisms linking inflammation to insulin resistance

L Chen, R Chen, H Wang… - International journal of …, 2015 - Wiley Online Library
Obesity is now widespread around the world. Obesity‐associated chronic low‐grade
inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a …

[HTML][HTML] Role of omentin, vaspin, cardiotrophin-1, TWEAK and NOV/CCN3 in obesity and diabetes development

X Escoté, S Gómez-Zorita, M López-Yoldi… - International journal of …, 2017 - mdpi.com
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the
effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of …

Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis

RW Grant, JM Stephens - American Journal of Physiology …, 2015 - journals.physiology.org
Adipose tissue has the largest capacity to store energy in the body and provides energy
through the release of free fatty acids during times of energy need. Different types of immune …

[HTML][HTML] Role of the TWEAK-Fn14-cIAP1-NF-κB signaling axis in the regulation of myogenesis and muscle homeostasis

EK Enwere, EC LaCasse, NJ Adam… - Frontiers in …, 2014 - frontiersin.org
Mammalian skeletal muscle maintains a robust regenerative capacity throughout life, largely
due to the presence of a stem cell population known as “satellite cells” in the muscle milieu …

To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling

P Javadpour, L Dargahi, A Ahmadiani… - Cellular and Molecular …, 2019 - Springer
Accumulating evidence has reached the consensus that the balance of phosphorylation
state of signaling molecules is a pivotal point in the regulation of cell signaling. Therefore …

[HTML][HTML] TWEAK: a new player in obesity and diabetes

J Vendrell, MR Chacón - Frontiers in immunology, 2013 - frontiersin.org
Obesity and type 2 diabetes (T2D) are associated with chronic low-grade inflammation.
Mounting evidence suggests the involvement of an inflammatory switch in adipose tissue …

Decreased secretion of tumor necrosis factor-α attenuates macrophages-induced insulin resistance in skeletal muscle

L Bu, X Cao, Z Zhang, H Wu, R Guo, M Ma - Life sciences, 2020 - Elsevier
Aims Macrophages, as an important member of immune system, engulf and digest
pathogens in innate immunity and help initiate adaptive immunity. However, macrophages …

TWEAK and monocyte to HDL ratio as a predictor of metabolic syndrome in patients with polycystic ovary syndrome

B Dincgez Cakmak, B Dundar… - Gynecological …, 2019 - Taylor & Francis
We aimed at analyzing serum TWEAK levels and monocyte/HDL ratio in polycystic ovary
syndrome (PCOS) and their predictivity for metabolic syndrome (MS) in PCOS. We included …

Visceral white adipose tissue and serum proteomic alternations in metabolically healthy obese patients undergoing bariatric surgery

IP Doulamis, P Konstantopoulos, A Tzani, A Antoranz… - Cytokine, 2019 - Elsevier
Metabolically healthy obesity is characterized as a comorbidity-free obesity status, however
the exact pathogenetic mechanisms implicated in its transition to unhealthy obesity have not …