A mitochondria-specific mutational signature of aging: increased rate of A> G substitutions on the heavy strand

AG Mikhailova, AA Mikhailova, K Ushakova… - Nucleic acids …, 2022 - academic.oup.com
The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the
known mutational signatures of the nuclear genome and variation in mtDNA mutational …

[PDF][PDF] A mitochondria-specific mutational signature of aging: increased rate of A> G substitutions on a heavy chain

AG Mikhaylova, AA Mikhailova, K Ushakova… - bioRxiv, 2022 - scholar.archive.org
The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the
known mutational signatures of the nuclear genome and variation in mtDNA mutational …

Mitochondrial mutational spectrum provides an universal marker of cellular and organismal longevity

AG Mikhaylova, AA Mikhailova, K Ushakova… - bioRxiv, 2019 - biorxiv.org
It has been shown recently that mitochondrial (mtDNA) somatic variants are numerous
enough to trace cellular lineages in our body. Here we extend this statement and …

Mitochondrial mutational spectrum is associated with mammalian longevity: a novel signature of oxidative damage

AG Mikhaylova, AA Mikhailova, K Ushakova… - bioRxiv, 2021 - biorxiv.org
The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the
known mutational signatures of the nuclear genome and variation in mtDNA mutational …