Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
Human haematopoietic stem cell development: from the embryo to the dish
Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …
haematopoietic system. Understanding how early haematopoietic development occurs is of …
Engineering in vitro immune-competent tissue models for testing and evaluation of therapeutics
JH Hammel, JM Zatorski, SR Cook… - Advanced drug delivery …, 2022 - Elsevier
Advances in 3D cell culture, microscale fluidic control, and cellular analysis have enabled
the development of more physiologically-relevant engineered models of human organs with …
the development of more physiologically-relevant engineered models of human organs with …
Multiple waves of fetal‐derived immune cells constitute adult immune system
M Kobayashi, M Yoshimoto - Immunological reviews, 2023 - Wiley Online Library
It has been over three decades since Drs. Herzenberg and Herzenberg proposed the
layered immune system hypothesis, suggesting that different types of stem cells with distinct …
layered immune system hypothesis, suggesting that different types of stem cells with distinct …
[HTML][HTML] Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution
G Rossi, S Giger, T Hübscher, MP Lutolf - Scientific Reports, 2022 - nature.com
Gastruloids are three-dimensional embryonic organoids that reproduce key features of early
mammalian development in vitro with unique scalability, accessibility, and spatiotemporal …
mammalian development in vitro with unique scalability, accessibility, and spatiotemporal …
Advances in gene therapy for fanconi anemia
Fanconi anemia (FA) is a rare inherited disease that is associated with bone marrow failure
and a predisposition to cancer. Previous clinical trials emphasized the difficulties that …
and a predisposition to cancer. Previous clinical trials emphasized the difficulties that …
Assessment of engineered cells using CellNet and RNA-seq
CellNet is a computational platform designed to assess cell populations engineered by
either directed differentiation of pluripotent stem cells (PSCs) or direct conversion, and to …
either directed differentiation of pluripotent stem cells (PSCs) or direct conversion, and to …
Notch and aryl hydrocarbon receptor signaling impact definitive hematopoiesis from human pluripotent stem cells
A Leung, E Zulick, N Skvir, K Vanuytsel… - Stem Cells, 2018 - academic.oup.com
Induced pluripotent stem cells (iPSCs) stand to revolutionize the way we study human
development, model disease, and eventually, treat patients. However, these cell sources …
development, model disease, and eventually, treat patients. However, these cell sources …
UniPath: a uniform approach for pathway and gene-set based analysis of heterogeneity in single-cell epigenome and transcriptome profiles
Recent advances in single-cell open-chromatin and transcriptome profiling have created a
challenge of exploring novel applications with a meaningful transformation of read-counts …
challenge of exploring novel applications with a meaningful transformation of read-counts …
[HTML][HTML] Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors
Q Zhang, B Wu, Q Weng, F Hu, Y Lin, C Xia… - Cellular & Molecular …, 2022 - nature.com
Regeneration of functional B lymphopoiesis from pluripotent stem cells (PSCs) is
challenging, and reliable methods have not been developed. Here, we unveiled the guiding …
challenging, and reliable methods have not been developed. Here, we unveiled the guiding …