The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

Advances in 3D cell culture, microscale fluidic control, and cellular analysis have enabled
the development of more physiologically-relevant engineered models of human organs with …

It has been over three decades since Drs. Herzenberg and Herzenberg proposed the
layered immune system hypothesis, suggesting that different types of stem cells with distinct …

Gastruloids are three-dimensional embryonic organoids that reproduce key features of early
mammalian development in vitro with unique scalability, accessibility, and spatiotemporal …

Fanconi anemia (FA) is a rare inherited disease that is associated with bone marrow failure
and a predisposition to cancer. Previous clinical trials emphasized the difficulties that …

CellNet is a computational platform designed to assess cell populations engineered by
either directed differentiation of pluripotent stem cells (PSCs) or direct conversion, and to …

Induced pluripotent stem cells (iPSCs) stand to revolutionize the way we study human
development, model disease, and eventually, treat patients. However, these cell sources …

Recent advances in single-cell open-chromatin and transcriptome profiling have created a
challenge of exploring novel applications with a meaningful transformation of read-counts …

Regeneration of functional B lymphopoiesis from pluripotent stem cells (PSCs) is
challenging, and reliable methods have not been developed. Here, we unveiled the guiding …