Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway

MA Elbaset, BMSA Mohamed, SA Gad, SM Afifi… - Scientific Reports, 2023 - nature.com
The kidney flushes out toxic substances and metabolic waste products, and homeostasis is
maintained owing to the kidney efforts. Unfortunately, kidney disease is one of the illnesses …

EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling

Y Luo, T Ali, Z Liu, R Gao, A Li, C Yang, L Ling, L He… - Life Sciences, 2023 - Elsevier
Aims Erythropoietin (EPO) is a glycoprotein cytokine that exerts therapeutic potential on
neurological disorders by promoting neurogenesis and angiogenesis. However, its role as …

Cellular and transcriptional diversity over the course of human lactation

SK Nyquist, P Gao, TKJ Haining… - Proceedings of the …, 2022 - National Acad Sciences
Human breast milk (hBM) is a dynamic fluid that contains millions of cells, but their identities
and phenotypic properties are poorly understood. We generated and analyzed single-cell …

Enhancing milk production by nutrient supplements: strategies and regulatory pathways

F Pan, P Li, G Hao, Y Liu, T Wang, B Liu - Animals, 2023 - mdpi.com
Simple Summary The demand for the milk and dairy products keeps growing due to the
growing population, the rising consumption of protein-enriched food, and other factors. Thus …

[HTML][HTML] Deoxynivalenol exposure inhibits biosynthesis of milk fat and protein by impairing tight junction in bovine mammary epithelial cells

X Zhao, P Sun, M Liu, S Liu, L Huo, Z Ding… - Ecotoxicology and …, 2022 - Elsevier
Deoxynivalenol (DON) is one of the most common feed contaminants, and it poses a serious
threat to the health of dairy cows. The existing studies of biological toxicity of DON mainly …

The potential role of targeting the leptin receptor as a treatment for breast cancer in the context of hyperleptinemia: a literature review

AS Neamah, AHS Wadan, FM Lafta… - … Archives of Pharmacology, 2024 - Springer
Since cancer is becoming a leading cause of death worldwide, efforts should be
concentrated on understanding its underlying biological alterations that would be utilized in …

miR-204-5p and miR-211 Synergistically Downregulate the αS1-Casein Content and Contribute to the Lower Allergy of Goat Milk

N Song, J Luo, L Huang, H Tian… - Journal of Agricultural …, 2021 - ACS Publications
αS1-Casein (encoded by the CSN 1 S 1 gene) is associated with higher rates of allergy than
other milk protein components for humans. microRNAs (miRNAs) as small noncoding RNA …

Mutation of Signal Transducer and Activator of Transcription 5 (STAT5) Binding Sites Decreases Milk Allergen αS1-Casein Content in Goat Mammary Epithelial Cells

N Song, J Luo, L Huang, S Zang, Q He, J Wu, J Huang - Foods, 2022 - mdpi.com
αS1-Casein (encoded by the CSN1S1 gene) is associated with food allergy more than other
milk protein components. Milk allergy caused by αS1-casein is derived from cow milk, goat …

Sweet taste receptor subunit T1R3 regulates casein secretion and phosphorylation of STAT5 in mammary epithelial cells

K Kobayashi, L Han, T Koyama, SN Lu… - Biochimica et Biophysica …, 2023 - Elsevier
During lactation, mammary epithelial cells (MECs) on the apical membrane are in contact
with lactose in milk, while MECs on the basolateral membrane are in contact with glucose in …

Modulation of Milk and Lipid Synthesis and Secretion in a3-Dimensional Mouse Mammary Epithelial Cell Culture Model: Effects of Palmitate and Orlistat

MG Ross, K Kobayashi, G Han, M Desai - Nutrients, 2022 - mdpi.com
Human milk synthesis is impacted by maternal diet, serum composition, and substrate
uptake and synthesis by mammary epithelial cells (MECs). The milk of obese/high-fat-diet …