Chromosomal aberrations (CA) are the microscopically visible part of a wide spectrum of
DNA changes generated by different repair mechanisms of DNA double strand breaks …

L'acétylation des histones, découverte il ya plus de 40 ans, est une modification réversible
des résidus lysine dans le domaine N terminal des histones du coeur. Les domaines N …

Based on the role of phosphorylation of the histone H2A variant H2AX in recruitment of DNA
repair and checkpoint proteins to the sites of DNA damage, we have investigated γH2AX as …

Histone deacetylase 6 (HDAC6) is structurally and functionally unique among the 11 human
zinc-dependent histone deacetylases. Here we show that chemical inhibition with the …

Transient DNA strand breaks are generated in the whole population of elongating
spermatids and are perfectly coincident with histone H4 hyperacetylation at chromatin …

Nuclear mitochondrial DNA sequences (NUMTs) are common in eukaryotes. However, the
mechanism by which they integrate into the nuclear genome remains a riddle. We analyzed …

DNA is under constant assault from genotoxic agents which creates different kinds of DNA
damage. The precise replication of the genome and the continuous surveillance of its …

The faithful repair of DNA double-strand breaks (DSBs) is probably one of the most critical
tasks for a cell in order to maintain its genomic integrity since these lesions may lead to …

This paper reviews the possible origin of sperm DNA fragmentation and focuses on the
nuclear events associated with spermiogenesis as a potential source of genetic instability …

Chromatin-remodelling mechanisms include DNA methylation, histone-tail acetylation, poly-
ADP-ribosylation, and ATP-dependent chromatin-remodelling processes. Some epigenetic …