Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

Oxidative stress greatly influences the pathogenesis of various cardiovascular disorders.
Coronary interventions, including balloon angioplasty and coronary stent implantation, are …

Aims Acquired long QT syndrome (aLQTS) exhibits QT prolongation and Torsades de
Pointes ventricular tachycardia triggered by drugs, hypokalaemia, or bradycardia …

Identification of potential human Ether-a-go-go Related-Gene (hERG) potassium channel
blockers is an essential part of the drug development and drug safety process in …

Background—Drugs with I Kr-blocking action cause secondary long-QT syndrome. Several
cases have been associated with mutations of genes coding cardiac ion channels, but their …

The human ether-a-go-go-related gene (hERG) encodes a channel that conducts the rapidly
activating delayed rectifier K+ current (IKr), which is important for cardiac repolarization …

Since the early 1990s, the concept of primary “inherited” arrhythmia syndromes or ion
channelopathies has evolved rapidly as a result of revolutionary progresses made in …

Human ether-á-go-go related gene (hERG, Kv11. 1) potassium channels play a significant
role in cardiac excitability. Like other Kv channels, hERG is activated by membrane voltage; …

We summarize recent advances in the clinical genetics of hypercholesterolemia,
hypertrophic cardiomyopathy (HCM), and lethal arrhythmia, all of which are monogenic …

Inherited human long-QT2 syndrome (LQTS) results from mutations in the gene encoding
the HERG channel. Several LQT2-associated mutations have been mapped to the amino …