Design, synthesis, and biological evaluation of potential prodrugs related to the experimental anticancer agent indotecan (LMP400)
PC Lv, MSA Elsayed, K Agama… - Journal of medicinal …, 2016 - ACS Publications
Indenoisoquinoline topoisomerase I (Top1) inhibitors are a novel class of anticancer agents
with two compounds in clinical trials. Recent metabolism studies of indotecan (LMP400) led …
with two compounds in clinical trials. Recent metabolism studies of indotecan (LMP400) led …
Species differences for stereoselective hydrolysis of propranolol prodrugs in plasma and liver
Y Yoshigae, T Imai, A Horita, M Otagiri - Chirality, 1997 - Wiley Online Library
Species differences and substrate specificities for the stereoselective hydrolysis of fifteen O‐
acyl propranolol (PL) prodrugs were investigated in pH 7.4 Tris‐HCl buffer and rat and dog …
acyl propranolol (PL) prodrugs were investigated in pH 7.4 Tris‐HCl buffer and rat and dog …
Novel approaches to prodrugs of anticancer diaminodichloroplatinum (II) complexes activated by stereoselective enzymatic ester hydrolysis
Y Kageyama, Y Yamazaki, H Okuno - Journal of inorganic biochemistry, 1998 - Elsevier
A series of dichloro (ethylenediamine)-type platinum complexes bearing ester-, amide-and
ether-bonded alkyl straight chains (C2–C18) was prepared as a model for the prodrug of cis …
ether-bonded alkyl straight chains (C2–C18) was prepared as a model for the prodrug of cis …
Difference between cancer cells and the corresponding normal tissue in view of stereoselective hydrolysis of synthetic esters
Y Yamazaki, Y Ogawa, AS Afify, Y Kageyama… - … et Biophysica Acta (BBA …, 1995 - Elsevier
This study has aimed at taking information necessary for design of anticancer prodrugs
modified with chiral acyl group, especially about the effect of chirality of the acyl group on its …
modified with chiral acyl group, especially about the effect of chirality of the acyl group on its …
Effect of fluorine substitution of α-and β-hydrogen atoms in ethyl phenylacetate and phenylpropionate on their stereoselective hydrolysis by cultured cancer cells
Y Yamazaki, S Yusa, Y Kageyama, H Tsue… - Journal of fluorine …, 1996 - Elsevier
(±)-Ethyl 2-fluoro-2-phenylacetate was stereoselectively hydrolyzed by cultured cells of
several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The …
several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The …
Stereoselective hydrolysis of xenobiotic esters by different cell lines from rat liver and hepatoma and its application to chiral prodrugs for designated growth …
YI Kageyama, Y Yamazaki, AS Afify, Y Ogawa… - Chirality, 1995 - Wiley Online Library
Stereoselectivity in the hydrolysis of racemic ethyl 2‐phenylacetate derivatives by cultured
cells of noncancerous cell lines from rat liver (BRL, BRL 3A, Clone 9, and ARLJ301–3) …
cells of noncancerous cell lines from rat liver (BRL, BRL 3A, Clone 9, and ARLJ301–3) …
[引用][C] Asymmetric induction in the electrochemical cross-coupling of aryl halides with α-chloropropionic acid derivatives catalyzed by nickel complexes
M Durandetti, J Périchon… - The Journal of Organic …, 1997 - ACS Publications
Several 2-arylpropanoic acids are known as important nonsteroidal pharmaceuticals
exhibiting antiinflammatory activity, 1 and many methods of preparation of these acids have …
exhibiting antiinflammatory activity, 1 and many methods of preparation of these acids have …