Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy

Y Liang, BM Lehrich, S Zheng… - Journal of Extracellular …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are released by many cell types and distributed within various
biofluids. EVs have a lipid membrane‐confined structure that allows for carrying unique …

Extracellular vesicles: techniques and biomedical applications related to single vesicle analysis

J Zhang, J Wu, G Wang, L He, Z Zheng, M Wu… - ACS …, 2023 - ACS Publications
Extracellular vesicles (EVs) are extensively dispersed lipid bilayer membrane vesicles
involved in the delivery and transportation of molecular payloads to certain cell types to …

Extracellular vesicles in cancer detection: hopes and hypes

T Hu, J Wolfram, S Srivastava - Trends in cancer, 2021 - cell.com
Early cancer diagnosis is critical for improving patient survival and mortality rates, but most
diagnostics on solid tumors rely on imaging tests with limited sensitivity and specificity to …

Advanced nanotechnologies for extracellular vesicle‐based liquid biopsy

L Min, B Wang, H Bao, X Li, L Zhao, J Meng… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are emerging as a new source of biomarkers in liquid biopsy
because of their wide presence in most body fluids and their ability to load cargoes from …

Accurate cancer diagnosis and stage monitoring enabled by comprehensive profiling of different types of exosomal biomarkers: surface proteins and miRNAs

S Zhou, T Hu, G Han, Y Wu, X Hua, J Su, W Jin, Y Mou… - Small, 2020 - Wiley Online Library
Exosomes are recognized as promising biomarkers for early cancer diagnosis and
prognosis owing to a large amount of biological information they carried. But the key is that …

A holistic review of the state‐of‐the‐art microfluidics for exosome separation: an overview of the current status, existing obstacles, and future outlook

L Ding, X Yang, Z Gao, CY Effah, X Zhang, Y Wu, L Qu - Small, 2021 - Wiley Online Library
Exosomes, a class of small extracellular vesicles (30–150 nm), are secreted by almost all
types of cells into virtually all body fluids. These small vesicles are attracting increasing …

Multiplexed profiling of extracellular vesicles for biomarker development

C Jiang, Y Fu, G Liu, B Shu, J Davis, GK Tofaris - Nano-micro letters, 2022 - Springer
Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in
molecular trafficking, intercellular transport and the egress of unwanted proteins. They have …

Ultrasensitive detection of mRNA in extracellular vesicles using DNA tetrahedron-based thermophoretic assay

Z Han, F Wan, J Deng, J Zhao, Y Li, Y Yang, Q Jiang… - Nano Today, 2021 - Elsevier
The analysis of messenger RNA (mRNA) in extracellular vesicles (EVs) may provide
unprecedented opportunities for non-invasive and rapid diagnosis of cancers. However …

Advanced technologies for molecular diagnosis of cancer: State of pre-clinical tumor-derived exosome liquid biopsies

L Li, L Zhang, KC Montgomery, L Jiang, CJ Lyon… - Materials Today Bio, 2023 - Elsevier
Exosomes are membrane-defined extracellular vesicles (EVs) approximately 40–160​ nm
in diameter that are found in all body fluids including blood, urine, and saliva. They act as …

A Review of Labeling Approaches Used in Small Extracellular Vesicles Tracing and Imaging

C Bao, H Xiang, Q Chen, Y Zhao, Q Gao… - International Journal …, 2023 - Taylor & Francis
Small extracellular vesicles (sEVs), a subset of extracellular vesicles (EVs) originating from
the endosomal compartment, are a kind of lipid bilayer vesicles released by almost all types …