Molecular physiology of cardiac repolarization
JM Nerbonne, RS Kass - Physiological reviews, 2005 - journals.physiology.org
The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …
potential generation and propagation, followed by relaxation and a period of refractoriness …
Calcium sparks
H Cheng, WJ Lederer - Physiological reviews, 2008 - journals.physiology.org
The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …
Gene variant effects across sodium channelopathies predict function and guide precision therapy
A Brunklaus, T Feng, T Brünger, E Perez-Palma… - Brain, 2022 - academic.oup.com
Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …
The genetic basis of long QT and short QT syndromes: a mutation update
PL Hedley, P Jørgensen, S Schlamowitz… - Human …, 2009 - Wiley Online Library
Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …
abnormalities that are characterized by length perturbations of the QT interval as measured …
Molecular pathophysiology of congenital long QT syndrome
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …
the fundamental cellular electrical event in the heart. The concerted function of these …
Inherited disorders of voltage-gated sodium channels
AL George - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm,
and nervous system function have been traced to mutations in genes encoding voltage …
and nervous system function have been traced to mutations in genes encoding voltage …
SCN5A Variants: Association With Cardiac Disorders
W Li, L Yin, C Shen, K Hu, J Ge, A Sun - Frontiers in physiology, 2018 - frontiersin.org
The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1. 5.
This channel predominates inward sodium current (INa) and plays a critical role in …
This channel predominates inward sodium current (INa) and plays a critical role in …
Cardiac ion channels
▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …
Computational biology in the study of cardiac ion channels and cell electrophysiology
Y Rudy, JR Silva - Quarterly reviews of biophysics, 2006 - cambridge.org
1. Prologue 582. The Hodgkin–Huxley formalism for computing the action potential 592.1
The axon action potential model 592.2 Cardiac action potential models 623. Ion-channel …
The axon action potential model 592.2 Cardiac action potential models 623. Ion-channel …
A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill
WA Groenewegen, M Firouzi, CR Bezzina… - Circulation …, 2003 - Am Heart Assoc
Atrial standstill (AS) is a rare arrhythmia that occasionally appears to be genetically
determined. This study investigates the genetic background of this arrhythmogenic disorder …
determined. This study investigates the genetic background of this arrhythmogenic disorder …