RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

BACKGROUND Colorectal cancer, for many years a prototypic model for the genetic basis of
cancer, is now increasingly cited as an exemplar of the role of epigenetic changes in …

In sporadic colorectal cancer (CRC), KRAS are alternative to BRAF mutations and occur,
respectively, in 30 and 10% of cases. Few reports addressed the association between KRAS …

5-methyl cytosine (5mC) is a key epigenetic mark entwined with gene expression and the
specification of cellular phenotypes. Its distribution around gene promoters sets a barrier for …

As the increased knowledge of tumour heterogeneity and genetic alterations progresses, it
exemplifies the need for further personalized medicine in modern cancer management …

AIM: Mitogen-activated protein kinase (MAPK) cascade and phosphatidylinositol 3-kinase
(PI3K) survival pathways are frequently activated in the progression of gastrointestinal …

Inhibition of the nonsense-mediated decay (NMD) mechanism in cells results in stabilization
of transcripts carrying premature translation termination codons. A strategy referred to as …

DNA methylation is the most frequent epigenetic alteration. Using methylation-specific
polymerase chain reaction (MSP), the methylation status of the adenomatous polyposis coli …

AIM: To evaluate the diagnostic role of serum RASSF1A promoter hypermethylation in
gastric and colorectal adenocarcinoma. METHODS: Methylation-specific polymerase chain …

The RAS‐association domain family, commonly referred to as RASSF, is a family of 10
members (RASSF1‐10) implicated in a variety of key biological processes, including cell …