Molecular mechanisms of ROS production and oxidative stress in diabetes

P Newsholme, VF Cruzat, KN Keane… - Biochemical …, 2016 - portlandpress.com
Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …

Exercise-stimulated glucose uptake—regulation and implications for glycaemic control

L Sylow, M Kleinert, EA Richter… - Nature Reviews …, 2017 - nature.com
Skeletal muscle extracts glucose from the blood to maintain demand for carbohydrates as an
energy source during exercise. Such uptake involves complex molecular signalling …

[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake

EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

Redox mechanism of reactive oxygen species in exercise

F He, J Li, Z Liu, CC Chuang, W Yang, L Zuo - Frontiers in physiology, 2016 - frontiersin.org
It is well known that regular exercise can benefit health by enhancing antioxidant defenses
in the body. However, unaccustomed and/or exhaustive exercise can generate excessive …

[HTML][HTML] Reactive oxygen species: The dual role in physiological and pathological conditions of the human body

SK Bardaweel, M Gul, M Alzweiri… - The Eurasian journal …, 2018 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) are well-known for playing a dual role as destructive and
constructive species. Indeed, ROS are engaged in many redox-governing activities of the …

Reactive oxygen species: from health to disease

K Brieger, S Schiavone, FJ Miller Jr, KH Krause - Swiss medical weekly, 2012 - smw.ch
Upon reaction with electrons, oxygen is transformed into reactive oxygen species (ROS). It
has long been known that ROS can destroy bacteria and destroy human cells, but research …

[HTML][HTML] Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

SA Mason, AJ Trewin, L Parker, GD Wadley - Redox biology, 2020 - Elsevier
Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …

Reactive oxygen species in health and disease

AA Alfadda, RM Sallam - BioMed research international, 2012 - Wiley Online Library
During the past decades, it became obvious that reactive oxygen species (ROS) exert a
multitude of biological effects covering a wide spectrum that ranges from physiological …

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

DC Liemburg-Apers, PHGM Willems… - Archives of …, 2015 - Springer
Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly
balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce …

Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling

Z Radak, Z Zhao, E Koltai, H Ohno… - Antioxidants & redox …, 2013 - liebertpub.com
The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …