Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Chymase is the most efficient Ang II (angiotensin II)–forming enzyme in the human body and
has been implicated in a wide variety of human diseases that also implicate its many other …

Antibody use is a critical component of cardiovascular physiology research, and antibodies
are used to monitor protein abundance (immunoblot analysis) and protein expression and …

The problem of inadequate statistical reporting is long standing and widespread in the
biomedical literature, including in cardiovascular physiology. Although guidelines for …

Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of
different acute (myocardial infarction) or chronic (diabetes, hypertension,…) diseases but …

Abstract Ethnopharmacological relevance Optimized New Shengmai Powder (ONSMP) is a
traditional Chinese medicine (TCM) formula for heart failure treatment. MAPK signaling …

Atherosclerosis is considered a disease caused by a chronic inflammation, associated with
endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects …

The classical view of the renin-angiotensin system (RAS) is that of the circulating hormone
pathway involved in salt and water homeostasis and blood pressure regulation. It is also …

Whereas hypertension, diabetes, and dyslipidemia are age-related risk factors for
cardiovascular disease (CVD) and chronic kidney disease (CKD), aging alone is an …

Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation of the
ERK1/2 and JNK1/2 signaling pathways of MAPK family members synergistically promotes …