Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors
develop, crosstalk between adipose tissue and cancer cells leads to changes in adipocyte …

T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic
agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the …

Immunotherapy is revolutionizing cancer treatment; however, complete responses are
achieved in only a small fraction of patients and tumor types. Thus, there is an urgent need …

The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains
debatable. Here, we discuss advances in several areas of human NK cell research, many of …

Natural killer (NK) cells can provide effective immunotherapy for ovarian cancer. Here, we
evaluated the ability of NK cells isolated from peripheral blood (PB) and NK cells derived …

One reason underlying the failure of current chimeric antigen receptor (CAR) immune
therapy to treat solid tumors adequately is insufficient tumor infiltration of CAR immune cells …

ABSTRACT Anti-PD-1/anti-PD-L1 therapies have shown success in cancer treatment but
responses are limited to~ 15% of patients with lymphocyte infiltrated, PD-L1 positive tumors …

Objective Natural killer (NK) cells are lymphocytes well suited for adoptive immunotherapy.
Attempts with adoptive NK cell immunotherapy against ovarian cancer have proven …

Objective Natural killer (NK) cells represent a powerful immunotherapeutic target as they
lyse tumors directly, do not require differentiation, and can elicit potent inflammatory …