Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …
variables pertaining to age, presence of metastases, extent of resection, histological …
Indian data on central nervous tumors: A summary of published work
A Dasgupta, T Gupta, R Jalali - South Asian journal of cancer, 2016 - thieme-connect.com
Tumors of the central nervous system (CNS) constitute approximately 2% of all
malignancies. Although relatively rare, the associated morbidity and mortality and the …
malignancies. Although relatively rare, the associated morbidity and mortality and the …
Tumor-associated macrophages in SHH subgroup of medulloblastomas
AS Margol, NJ Robison, J Gnanachandran… - Clinical Cancer …, 2015 - AACR
Purpose: Medulloblastoma in children can be categorized into at least four molecular
subgroups, offering the potential for targeted therapeutic approaches to reduce treatment …
subgroups, offering the potential for targeted therapeutic approaches to reduce treatment …
Subgroup-specific diagnostic, prognostic, and predictive markers influencing pediatric medulloblastoma treatment
S Ray, NK Chaturvedi, KK Bhakat, A Rizzino… - Diagnostics, 2021 - mdpi.com
Medulloblastoma (MB) is the most common malignant central nervous system tumor in
pediatric patients. Mainstay of therapy remains surgical resection followed by craniospinal …
pediatric patients. Mainstay of therapy remains surgical resection followed by craniospinal …
Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy
S Blüml, AS Margol, R Sposto, RJ Kennedy… - Neuro …, 2015 - academic.oup.com
Background Medulloblastomas in children can be categorized into 4 molecular subgroups
with differing clinical characteristics, such that subgroup determination aids in …
with differing clinical characteristics, such that subgroup determination aids in …
Nomograms based on preoperative multiparametric magnetic resonance imaging for prediction of molecular subgrouping in medulloblastoma: results from a …
A Dasgupta, T Gupta, S Pungavkar, N Shirsat… - Neuro …, 2019 - academic.oup.com
Background Novel biological insights have led to consensus classification of
medulloblastoma into 4 distinct molecular subgroups—wingless (WNT), sonic hedgehog …
medulloblastoma into 4 distinct molecular subgroups—wingless (WNT), sonic hedgehog …
Integrating molecular subclassification of medulloblastomas into routine clinical practice: a simplified approach
Medulloblastoma (MB) is composed of four molecular subgroups viz. WNT, SHH, groups 3
and 4, identified using various high‐throughput methods. Translation of this molecular data …
and 4, identified using various high‐throughput methods. Translation of this molecular data …
Glioma exosomal microRNA-148a-3p promotes tumor angiogenesis through activating the EGFR/MAPK signaling pathway via inhibiting ERRFI1
M Wang, Y Zhao, ZY Yu, RD Zhang, SA Li… - Cancer cell …, 2020 - Springer
Background Glioma is the most frequent and lethal primary brain malignancy. Amounting
evidence has highlighted the importance of exosomal microRNAs (miRNAs or miRs) in this …
evidence has highlighted the importance of exosomal microRNAs (miRNAs or miRs) in this …
Omission of upfront craniospinal irradiation in patients with low-risk WNT-pathway medulloblastoma is associated with unacceptably high risk of neuraxial failure
T Gupta, S Pervez, A Dasgupta, A Chatterjee… - Clinical Cancer …, 2022 - AACR
Purpose: Medulloblastoma is a heterogenous disease comprising four molecular
subgroups: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4, respectively …
subgroups: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4, respectively …
Outcomes of salvage re-irradiation in recurrent medulloblastoma correlate with age at initial diagnosis, primary risk-stratification, and molecular subgrouping
T Gupta, M Maitre, GJ Sastri, R Krishnatry… - Journal of Neuro …, 2019 - Springer
Purpose To report outcomes of salvage re-irradiation (re-RT) in recurrent/progressive
medulloblastoma (MB). Methods Medical records of patients treated with curative-intent re …
medulloblastoma (MB). Methods Medical records of patients treated with curative-intent re …