In the mid-1970s, an intense race to identify endogenous substances that activated the
same receptors as opiates resulted in the identification of the first endogenous opioid …

Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with
overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve …

Despite high mortality rates due to opioid overdose and excessive alcohol consumption,
medications for the treatment of alcohol and opioid use disorder have not been widely used …

Background Naltrexone is a nonselective opioid receptor antagonist used as a treatment for
alcohol use disorder. However, only modest clinical effects have been observed, possibly …

Substance use disorders (SUDs) constitute a growing global health crisis, yet many
limitations and challenges exist in SUD treatment research, including the lack of objective …

Alcohol use disorder (AUD) is the most prevalent substance use disorder and causes a
significant global burden. Relapse rates remain incredibly high after decades of attempting …

Background Cocaine use disorder (CUD) has significant consequences and there remain
no FDA-approved pharmacotherapies. Ondansetron is an indirect dopaminergic modulator …

Randomized controlled trials (RCTs) evaluating medications for alcohol use disorder (AUD)
often examine heterogeneity of treatment effects through subgroup analyses that contrast …

Abstract Background and Objectives Alcohol use disorder (AUD) is common and causes
significant morbidity and mortality. Currently approved medications are moderately effective …

Bislang sind nur wenige Medikamente zur pharmakologischen Rückfallprophylaxe der
Alkoholabhängigkeit zugelassen. Neben dem in Deutschland nicht mehr vertriebenen …