Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering

MA Velasco, CA Narváez-Tovar… - BioMed research …, 2015 - Wiley Online Library
A review about design, manufacture, and mechanobiology of biodegradable scaffolds for
bone tissue engineering is given. First, fundamental aspects about bone tissue engineering …

The rational use of animal models in the evaluation of novel bone regenerative therapies

M Peric, I Dumic-Cule, D Grcevic, M Matijasic… - Bone, 2015 - Elsevier
Bone has a high potential for endogenous self-repair. However, due to population aging,
human diseases with impaired bone regeneration are on the rise. Current strategies to …

BMPs in bone regeneration: Less is more effective, a paradigm-shift

K Schmidt-Bleek, BM Willie, P Schwabe… - Cytokine & growth factor …, 2016 - Elsevier
Worldwide, the clinical application of BMP2 (bone morphogenetic protein 2) has helped an
increasing number of patients achieve bone regeneration in a clinical area lacking simple …

Current therapeutic approach to hypertrophic scars

ZB Mokos, A Jović, L Grgurević, I Dumić-Čule… - Frontiers in …, 2017 - frontiersin.org
Abnormal scarring and its accompanying esthetic, functional, and psychological sequelae
still pose significant challe nges. To date, there is no satisfactory prevention or treatment …

[HTML][HTML] Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity

J Yang, P Shi, M Tu, Y Wang, M Liu, F Fan… - Food Science and Human …, 2014 - Elsevier
Bone morphogenetic proteins (BMPs) are a family of potent, multifunctional growth factors
belonging to transforming growth factor-β (TGF-β). They are highly conservative in …

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

E Augustyniak, T Trzeciak, M Richter… - International …, 2015 - Springer
Purpose The use of stem cells in regenerative medicine offers hope to treat numerous
orthopaedic disorders, including articular cartilage defects. Although much research has …

[HTML][HTML] Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar …

L Grgurevic, I Erjavec, M Gupta, M Pecin… - Bone, 2020 - Elsevier
In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of
recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) …

Antibacterial sequential growth factor delivery from alginate/gelatin methacryloyl microspheres for bone regeneration

M Dai, X Lin, P Hua, S Wang, X Sun, C Tang… - International Journal of …, 2024 - Elsevier
Autologous or allogeneic bone tissue grafts remain the mainstay of treatment for clinical
bone defects. However, the risk of infection and donor scarcity in bone grafting pose …

[HTML][HTML] Genome-wide identification, phylogeny and expression analysis of the bmp gene family associated with development and skeleton deformity in cobia …

Q Ma, Y Yang, F Mao, Q Zhou, L Wang, G Chen - Aquaculture Reports, 2023 - Elsevier
Bone morphogenetic proteins (BMPs) are critical for controlling skeletal development of fish,
which has significant influence on external morphology, functional exercise and even …

Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits

L Grgurevic, H Oppermann, M Pecin, I Erjavec… - JBMR …, 2019 - Wiley Online Library
ABSTRACT BMP2 and BMP7, which use bovine Achilles tendon–derived absorbable
collagen sponge and bovine bone collagen as scaffold, respectively, have been approved …