Ageing and rejuvenation of tissue stem cells and their niches

A Brunet, MA Goodell, TA Rando - Nature Reviews Molecular Cell …, 2023 - nature.com
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Immune and inflammatory networks in myocardial infarction: current research and its potential implications for the clinic

A Anzai, S Ko, K Fukuda - International journal of molecular sciences, 2022 - mdpi.com
Despite recent scientific and technological advances, myocardial infarction (MI) still
represents a major global health problem, leading to high morbidity and mortality worldwide …

Monocytes re-enter the bone marrow during fasting and alter the host response to infection

H Janssen, F Kahles, D Liu, J Downey, LL Koekkoek… - Immunity, 2023 - cell.com
Diet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via
its influence on immunity and metabolism, caloric restriction and fasting appear to be …

Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review

GA Figtree, ST Vernon, JA Harmer, MP Gray… - Journal of the American …, 2023 - jacc.org
Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors
(SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD) …

Adherence to the Mediterranean diet: impact of geographical location of the observations

E Mattavelli, E Olmastroni, D Bonofiglio, AL Catapano… - Nutrients, 2022 - mdpi.com
The Mediterranean diet has emerged as a comprehensive lifestyle, including specific foods
and meal composition and a set of behavioural and social features. Adherence to the …

Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials

NA Marston, JP Pirruccello, GEM Melloni, F Kamanu… - Nature Medicine, 2024 - nature.com
Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with an
increased risk of cardiovascular (CV) disease in the general population. Currently, it is …

Wearable accelerometer-derived physical activity and incident disease

S Khurshid, LC Weng, V Nauffal, JP Pirruccello… - NPJ Digital …, 2022 - nature.com
Physical activity is regarded as favorable to health but effects across the spectrum of human
disease are poorly quantified. In contrast to self-reported measures, wearable …

Genomic aging, clonal hematopoiesis, and cardiovascular disease

P Natarajan - Arteriosclerosis, thrombosis, and vascular biology, 2023 - Am Heart Assoc
Chronologic age is the dominant risk factor for coronary artery disease but the features of
aging promoting coronary artery disease are poorly understood. Advances in human …

Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities

I Mitroulis, G Hajishengallis… - Cardiovascular …, 2023 - academic.oup.com
Abstract Cardiometabolic disorders are chief causes of morbidity and mortality, with chronic
inflammation playing a crucial role in their pathogenesis. The release of differentiated …

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis

MM Uddin, S Saadatagah, A Niroula, B Yu… - Nature …, 2024 - nature.com
Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …