Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

Atherosclerosis is a chronic inflammatory disease that is characterized by the formation of
lipid rich plaques in the wall of medium to large sized arteries. Atherothrombosis represents …

To diminish the learning curve associated with using swine as models, Swine in the
Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition …

Clinical trials report that the class of drugs known as statins may be neuroprotective in
Alzheimer's and Parkinson's disease, and further trials are currently underway to test …

Atherosclerosis and thrombosis associated with the rupture of vulnerable plaque are the
main causes of cardiovascular events, including acute coronary syndrome. Low-density …

The human cardiovascular system is a complex arrangement of specialized structures with
distinct functions. The molecular landscape, including the genome, transcriptome and …

Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with
platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease …

Lysyl oxidase (LOX) plays a crucial role in the maintenance of extracellular matrix stability
and could participate in vascular remodelling associated with cardiovascular diseases …

Hyperlipidaemia is a well‐established risk factor for cardiovascular diseases and therefore,
many animal model have been developed to mimic the human abnormal elevation of blood …

Atherosclerosis and its thrombotic complications are responsible for remarkably high
numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental …