Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

Vitamin D production in the skin under the influence of sunlight (UVB) is maximized at levels
of sunlight exposure that do not burn the skin. Further metabolism of vitamin D to its major …

Colony-forming human epidermal cells are heterogeneous in their capacity for sustained
growth. Once a clone has been derived from a single cell, its growth potential can be …

Normal human cells exhibit a limited replicative life span in culture, eventually arresting
growth by a process termed senescence. Progressive telomere shortening appears to …

The relationship of cell proliferation to the temporal expression of genes characterizing a
developmental sequence associated with bone cell differentiation can be examined in …

Hair follicle (HF) regeneration begins when communication between quiescent epithelial
stem cells (SCs) and underlying mesenchymal dermal papillae (DP) generates sufficient …

A specialized tissue type, the keratinizing epithelium, protects terrestrial mammals from
water loss and noxious physical, chemical and mechanical insults. This barrier between the …

The skin is essential for survival and protects our body against biological attacks, physical
stress, chemical injury, water loss, ultraviolet radiation and immunological impairment. The …

Sunlight influences the physiology of the human skin in beneficial as well as harmful ways,
as has been shown for UV light. However, little is known about the effects of other …

N the past ten years, there have been a number of major scientific discoveries in the field of
epidermal differentiation. We owe many of these findings to the development of model tissue …