The influenza virus polymerase complex: an update on its structure, functions, and significance for antiviral drug design
A Stevaert, L Naesens - Medicinal research reviews, 2016 - Wiley Online Library
Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …
[HTML][HTML] Progress of small molecular inhibitors in the development of anti-influenza virus agents
X Wu, X Wu, Q Sun, C Zhang, SY Yang, L Li, Z Jia - Theranostics, 2017 - ncbi.nlm.nih.gov
The influenza pandemic is a major threat to human health, and highly aggressive strains
such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to …
such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to …
The complete synthesis of favipiravir from 2-aminopyrazine
Q Guo, M Xu, S Guo, F Zhu, Y Xie, J Shen - Chemical Papers, 2019 - Springer
Favipiravir was first synthesized from an inexpensive and commercially available starting
material, 2-aminopyrazine. The preferred route embedded within Scheme 4 consisted of …
material, 2-aminopyrazine. The preferred route embedded within Scheme 4 consisted of …
Pyrazine Moiety: Recent Developments in Cancer Treatment
Cancer is becoming more common worldwide, impacting the vast majority of people. As a
result, new anticancer drugs are currently being created, and their safety is still being …
result, new anticancer drugs are currently being created, and their safety is still being …
[HTML][HTML] Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza Part II: Future compounds …
R Gasparini, D Amicizia, PL Lai… - Journal of preventive …, 2014 - ncbi.nlm.nih.gov
In the first part of this overview, we described the life cycle of the influenza virus and the
pharmacological action of the currently available drugs. This second part provides an …
pharmacological action of the currently available drugs. This second part provides an …
FTIR spectroscopic evidence for new isomers of 3-aminopyrazine-2-carboxylic acid formed in argon matrices upon UV irradiations
M Pagacz-Kostrzewa, K Mucha, W Gul… - … Acta Part A: Molecular …, 2021 - Elsevier
The UV-induced photochemistry and molecular structure of 3-aminopyrazine-2-carboxylic
acid were studied in argon matrices by Fourier-transform infrared spectroscopy and …
acid were studied in argon matrices by Fourier-transform infrared spectroscopy and …
Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents
C Lin, C Sun, X Liu, Y Zhou, M Hussain, J Wan, M Li… - Antiviral research, 2016 - Elsevier
Among many subtypes of influenza A viruses, influenza A (H1N1) and A (H3N2) subtypes
are currently circulating among humans (WHO report 2014–15). Therapeutically, the …
are currently circulating among humans (WHO report 2014–15). Therapeutically, the …
New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity
Y Xiong, P Yi, Y Li, R Gao, J Chen, Z Hu… - Natural Product …, 2022 - Taylor & Francis
Phytochemical studies led to the isolation of five new sesquiterpeniod esters, named
balsamiferine NR, along with ten known compounds (6-15) from the leaves of Blumea …
balsamiferine NR, along with ten known compounds (6-15) from the leaves of Blumea …
Harnessing the Pyrazine Moiety for Potent Anti-inflammatory Activity: A Comprehensive Review
Inflammation is an intricate physiological reaction that has a vital function in the body's
protection against detrimental stimuli. Nevertheless, uncontrolled inflammation may result in …
protection against detrimental stimuli. Nevertheless, uncontrolled inflammation may result in …
A comprehensive update on the structure and synthesis of potential drug targets for combating the coronavirus pandemic caused by SARS‐CoV‐2
P Malik, S Jain, P Jain, J Kumawat… - Archiv der …, 2022 - Wiley Online Library
The outbreak of the coronavirus pandemic COVID‐19 created by its severe acute respiratory
syndrome corona virus‐2 (SARS‐CoV‐2) variant, known for producing a very severe acute …
syndrome corona virus‐2 (SARS‐CoV‐2) variant, known for producing a very severe acute …