Mechanotransduction, the translation of mechanical stimuli into biological signals, is a
crucial mechanism involved in the function of fundamentally all cell types. In many solid …

In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …

Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks
of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase …

Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter
representing the leading cause of death in cancer patients. Whilst many advances in this …

Psoriasis is an immune disease of the skin that frequently develops upon triggering events
of mechanical nature and leads to increased proliferation and damaged differentiation of …

Mechanical forces are central to how cancer treatments such as chemotherapeutics and
immunotherapies interact with cells and tissues. At the simplest level, electrostatic forces …

Caveolae are bulb-like invaginations made up of two essential structural proteins, caveolin-
1 and cavins, which are abundantly present at the plasma membrane of vertebrate cells …

During intravasation, cancer cells cross the endothelial barrier and enter the circulation.
Extracellular matrix stiffening has been correlated with tumor metastatic potential; however …

In the present study we investigated the expression and the functional role of
mechanosensitive polycystins in renal cell carcinoma (RCC). In 115 RCC patients we …

Modifications on shear stress‐based mechanical forces are associated with
pathophysiological susceptibility and their effect on endothelial cells (EC) needs to be better …