The gastrointestinal tract is continuously exposed to trillions of commensal microbes,
collectively termed the microbiota, which are environmental stimuli that can direct health and …

Intestinal microbiota are involved in the pathogenesis of Crohn's disease, ulcerative colitis,
and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses …

Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell
cycle and are required for the initiation and progression of various malignancies …

The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

CD4+ T cells are crucial for directing appropriate immune responses during host defense
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …

Background & Aims Regulatory T cell (Treg) depletion increases antitumor immunity.
However, severe autoimmunity can occur following systemic loss of Tregs, which could be …

Foxp3+ regulatory T cells (Tregs) maintain immune tolerance and play an important role in
immunological diseases and cancers. Recent studies have revealed an intricate relationship …

The diverse microbial populations constituting the intestinal microbiota promote immune
development and differentiation, but because of their complex metabolic requirements and …

Defining the etiology of inflammatory bowel disease (IBD) continues to elude researchers, in
part due to the possibility that there may be different triggers for a spectrum of disease …

Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent
kinase 4 (CDK4) and CDK6, have attracted considerable interest as potential targets for …