L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …

Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

The mucosal vascular addressin, MAdCAM-1, is an immunoglobulin superfamily adhesion
molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte …

Single-cell transcriptomics promise to revolutionize our understanding of the vasculature.
Emerging computational methods applied to high-dimensional single-cell data allow …

One decade ago, vascular endothelium was commonly considered a" non-stick" lining of
blood vessels that functioned only to prevent blood coagulation and to separate the vascular …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

The circulatory and migratory properties of white blood cells have evolved to allow efficient
surveillance of tissues for infectious pathogens and rapid accu ญ mulation at sites of injury …

Understanding the molecular basis of lymphocyte homing to lymphoid organs was originally
a problem of concern only to immunologists. With the discovery of l-selectin and its ligands …

Lymph nodes (LNs) are highly organized secondary lymphoid organs that mediate adaptive
immune responses to antigens delivered via afferent lymphatic vessels. Lymphatic …

Perspectives Page 1 Perspectives Selectins Michael P. Bevilacqua and Richard M. Nelson
Howard Hughes Medical Institute, Cellular and Molecular Medicine andDepartment ofPathology …