Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …

The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to
evasion of the host immune system. The relative importance of the tumor microenvironment …

During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and
colonize target organs. Here, we examined the role of interleukin (IL)-22 in metastasis …

Increasing evidence suggests that platelets play a predominant role in colon and breast
cancer metastasis, but the underlying molecular mechanisms remain elusive. Glycoprotein …

The lung is a vital organ that incessantly faces external environmental challenges. Its
homeostasis and unimpeded vital function are ensured by the respiratory epithelium …

Abstract KRASG12C inhibitors, including MRTX849, are promising treatment options for
KRAS-mutant non–small cell lung cancer (NSCLC). PD-1 inhibitors are approved in NSCLC; …

Although T cells can exert potent anti-tumor immunity, a subset of T helper (Th) cells
producing interleukin-22 (IL-22) in breast and lung tumors is linked to dismal patient …

The NRAS gene is a well-known oncogene that acts as a major player in carcinogenesis.
Mutations in the NRAS gene have been linked to multiple types of human tumors. Therefore …

Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers.
While we previously identified KRAS mutations as molecular culprits of MPE formation, the …

Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity
of asbestos‐exposed individuals and rapidly leads to death. MPM harbors loss‐of‐function …