Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

In Trypanosoma brucei, the editosome, composed of RNA-editing substrate-binding
complex (RESC) and RNA-editing catalytic complex (RECC), orchestrates guide RNA …

Translation in mitochondria is mediated by mitochondrial ribosomes, or mitoribosomes,
complex ribonucleoprotein machines with dual genetic origin. Mitoribosomes in …

ATP hydrolysis is required for the synthesis, transport and polymerization of monomers for
macromolecules as well as for the assembly of the latter into cellular structures. Other …

Trypanosomatids are single-cell eukaryotic parasites. Unlike higher eukaryotes, they control
gene expression post-transcriptionally and not at the level of transcription initiation. This …

Since the first identification of circular RNA (circRNA) in viral-like systems, reports of
circRNAs and their functions in various organisms, cell types, and organelles have greatly …

Unicellular parasites Trypanosoma brucei spp. cause African human and animal
trypanosomiasis, a spectrum of diseases that jeopardize public health and afflict the …

In Trypanosoma brucei, most mitochondrial mRNAs undergo editing, and 3′ adenylation
and uridylation. The internal sequence changes and terminal extensions are coordinated …

RNA-binding proteins play a particularly important role in regulating gene expression in
trypanosomes. A map of the network of protein complexes in Trypanosoma brucei …

In Trypanosoma brucei, mitochondrial pre-mRNAs undergo 3′-5′ exonucleolytic
processing, 3′ adenylation and uridylation, 5′ pyrophosphate removal, and, often, U …