Single-cell image analysis provides a powerful approach for studying cell-to-cell
heterogeneity, which is an important attribute of isogenic cell populations, from microbial …

Wine yeast have been exposed to harsh conditions for millennia, which have led to adaptive
evolutionary strategies. Thus, wine yeasts from Saccharomyces genus are considered an …

Our ability to understand the genotype‐to‐phenotype relationship is hindered by the lack of
detailed understanding of phenotypes at a single‐cell level. To systematically assess cell‐to …

Here, we introduce YeastMate, a user-friendly deep learning-based application for
automated detection and segmentation of Saccharomyces cerevisiae cells and their mating …

In the past 15 years, cell-based microscopy has evolved its focus from observing cell
function to aiming to predict it. In particular—powered by breakthroughs in computer vision …

Covering: up to 2019 Nature furnishes bioactive compounds (natural products) with complex
chemical structures, yet with simple, sophisticated molecular mechanisms. When natural …

Although evolution by natural selection is widely regarded as the most important principle of
biology, it is unknown whether phenotypic variations within and between species are mostly …

Several industries require getting information of products as soon as possible during
fermentation. However, the trade-off between sensing speed and data quantity presents …

Haploinsufficiency, a dominant phenotype caused by a heterozygous loss-of-function
mutation, has been rarely observed. However, high-dimensional single-cell phenotyping of …

Sake yeast was first isolated as a single yeast strain, Saccharomyces sake, during the Meiji
era. Yeast strains suitable for sake fermentation were subsequently isolated from sake …