[HTML][HTML] Serine peptidase inhibitor Kunitz type 2 (SPINT2) in cancer development and progression

FM Roversi, STO Saad, JA Machado-Neto - Biomedicine & …, 2018 - Elsevier
Understanding the molecular basis and mechanisms involved in neoplastic transformation
and progression is important for the development of novel selective target therapeutic …

A molecular classification of human mesenchymal stromal cells

F Rohart, EA Mason, N Matigian, R Mosbergen, O Korn… - PeerJ, 2016 - peerj.com
Mesenchymal stromal cells (MSC) are widely used for the study of mesenchymal tissue
repair, and increasingly adopted for cell therapy, despite the lack of consensus on the …

Up‐regulation of SPINT 2/HAI‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion

FM Roversi, NM Cury, MR Lopes… - Journal of Cellular …, 2019 - Wiley Online Library
The role of tumour microenvironment in neoplasm initiation and malignant evolution has
been increasingly recognized. However, the bone marrow mesenchymal stromal cell …

GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

L Guerenne, S Beurlet, M Said, P Gorombei… - Journal of hematology & …, 2016 - Springer
Background In spite of the recent discovery of genetic mutations in most myelodysplasic
(MDS) patients, the pathophysiology of these disorders still remains poorly understood, and …

Menatetrenone facilitates hematopoietic cell generation in a manner that is dependent on human bone marrow mesenchymal stromal/stem cells

A Fujishiro, M Iwasa, S Fujii, T Maekawa… - International journal of …, 2020 - Springer
Vitamin K2 in the form of menatetrenone has clinical benefits for osteoporosis and
cytopenia. Given the dominant role of mesenchymal-osteolineage cells in the regulation of …

The Role of HAI-2 in the Intestine Depends on Its Correct Subcellular Targeting

N Huang - 2024 - search.proquest.com
The hepatocyte growth factor activator inhibitor 1 (HAI-1) and HAI-2 are two closely related
type I transmembrane Kunitz type serine protease inhibitors, that consist of two homologous …

[HTML][HTML] 骨髓增生异常综合征骨髓微环境异常的研究进展

董培源, 黄丽芳, 孙汉英 - Chinese Journal of Hematology, 2017 - ncbi.nlm.nih.gov
骨髓增生异常综合征(MDS) 的发病机制包括基因, 表观遗传学, 凋亡, 分化和细胞因子环境的异常
等. 造血干细胞(HSC) 与骨髓基质细胞, 微环境分泌的细胞因子或化学因子之间的相互作用是 …

On a route from whole genome duplication to aneuploidy and cancer: consequences and adaptations

S Bernhard - 2022 - kluedo.ub.rptu.de
Whole genome duplication (WGD) is commonly accepted as an intermediate state between
healthy cells and aneuploid cancer cells. Usually, cells after WGD get removed from the …

Research progress of bone marrow microenvironment abnormalities in myelodysplastic syndrome

PY Dong, LF Huang, HY Sun - Zhonghua xue ye xue za zhi …, 2017 - europepmc.org
骨髓增生异常综合征 (MDS) 的发病机制包括基因, 表观遗传学, 凋亡, 分化和细胞因子环境的
异常等. 造血干细胞 (HSC) 与骨髓基质细胞, 微环境分泌的细胞因子或化学因子之间的相互作用 …

[引用][C] 骨髓微环境与骨髓增生异常综合征

吕扬扬, 赵智刚 - 天津医药, 2018