[HTML][HTML] The role of macrophages in HIV-1 persistence and pathogenesis
Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS
AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
Autophagy is a cytoplasmic degradative pathway that can participate in biosynthetic
processes, as in the yeast Cvt pathway, but is more commonly known for its functions in …
processes, as in the yeast Cvt pathway, but is more commonly known for its functions in …
Mechanisms of HIV-associated lymphocyte apoptosis: 2010
NW Cummins, AD Badley - Cell death & disease, 2010 - nature.com
The inevitable decline of CD4T cells in untreated infection with the Human
immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell …
immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell …
Mechanisms of HIV-associated lymphocyte apoptosis
Infection with the human immunodeficiency virus (HIV) is associated with a progressive
decrease in CD4 T-cell number and a consequent impairment in host immune defenses …
decrease in CD4 T-cell number and a consequent impairment in host immune defenses …
Targeting TNF and TNF receptor pathway in HIV-1 infection: from immune activation to viral reservoirs
Several cellular functions such as apoptosis, cellular proliferation, inflammation, and
immune regulation involve the tumor necrosis factor-α (TNF)/TNF receptor (TNFR) pathway …
immune regulation involve the tumor necrosis factor-α (TNF)/TNF receptor (TNFR) pathway …
HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention
M Kogan, J Rappaport - Retrovirology, 2011 - Springer
The HIV protein, Vpr, is a multifunctional accessory protein critical for efficient viral infection
of target CD4+ T cells and macrophages. Vpr is incorporated into virions and functions to …
of target CD4+ T cells and macrophages. Vpr is incorporated into virions and functions to …
Apoptosis as an HIV strategy to escape immune attack
ML Gougeon - Nature Reviews Immunology, 2003 - nature.com
Viruses have evolved numerous mechanisms to evade the host immune system and one of
the strategies developed by HIV is to activate apoptotic programmes that destroy immune …
the strategies developed by HIV is to activate apoptotic programmes that destroy immune …
The Vpr protein from HIV-1: distinct roles along the viral life cycle
E Le Rouzic, S Benichou - Retrovirology, 2005 - Springer
The genomes of human and simian immunodeficiency viruses (HIV and SIV) encode the
gag, pol and env genes and contain at least six supplementary open reading frames termed …
gag, pol and env genes and contain at least six supplementary open reading frames termed …
[HTML][HTML] HIV‐1 Tat targets microtubules to induce apoptosis, a process promoted by the pro‐apoptotic Bcl‐2 relative Bim
Depletion of CD4+ T cells is the hallmark of HIV infection and AIDS progression. In addition
to the direct killing of the viral‐infected cells, HIV infection also leads to increased apoptosis …
to the direct killing of the viral‐infected cells, HIV infection also leads to increased apoptosis …