The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is
localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm …

NPM1-mutated acute myeloid leukemia (AML) represents the largest molecular subgroup of
adult AML. NPM1-mutated AML is recognizable by molecular techniques and …

NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated
nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies' …

Acute Myeloid Leukemia (AML) is a highly heterogeneous disease with 3-year patient
survival ranging from 30 to 80%, depending on molecular characteristics. Mutations in …

Gain-of-function mutations in the histone acetylation “reader” eleven-nineteen-leukemia
(ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive …

Numerous cellular processes occur in the context of condensates, a type of large,
membrane-less biomolecular assembly generated through phase separation. These …

As key developmental regulators, HOX cluster genes have varied and context-specific roles
in normal and malignant hematopoiesis. A complex interaction of transcription factors …

Acute myeloid leukemia (AML) is the most aggressive adult leukemia, characterized by
clonal differentiation arrest of progenitor or precursor hematopoietic cells. Intense preclinical …

Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1
expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein …

Given the remarkable overall response rates, shedding light on treatment options for
patients whose leukemias develop resistance to Menin inhibitors is an imminent clinical …