The multi-functional Smc5/6 complex in genome protection and disease
XP Peng, X Zhao - Nature Structural & Molecular Biology, 2023 - nature.com
Structural maintenance of chromosomes (SMC) complexes are ubiquitous genome
regulators with a wide range of functions. Among the three types of SMC complexes in …
regulators with a wide range of functions. Among the three types of SMC complexes in …
A walk through the SMC cycle: From catching DNAs to shaping the genome
R Oldenkamp, BD Rowland - Molecular cell, 2022 - cell.com
SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
DNA segment capture by Smc5/6 holocomplexes
M Taschner, S Gruber - Nature Structural & Molecular Biology, 2023 - nature.com
Three distinct structural maintenance of chromosomes (SMC) complexes facilitate
chromosome folding and segregation in eukaryotes, presumably by DNA loop extrusion …
chromosome folding and segregation in eukaryotes, presumably by DNA loop extrusion …
Smc5/6's multifaceted DNA binding capacities stabilize branched DNA structures
JTH Chang, S Li, EC Beckwitt, T Than… - Nature …, 2022 - nature.com
Smc5/6 is an evolutionarily conserved SMC complex with roles in DNA replication and
repair, as well as in viral DNA restriction. Understanding its multiple functions has been …
repair, as well as in viral DNA restriction. Understanding its multiple functions has been …
Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions
The Smc5/6 complex (Smc5/6) is important for genome replication and repair in eukaryotes.
Its cellular functions are closely linked to the ATPase activity of the Smc5 and Smc6 …
Its cellular functions are closely linked to the ATPase activity of the Smc5 and Smc6 …
[HTML][HTML] Structural biology of SMC complexes across the tree of life
Structural maintenance of chromosomes (SMC) complexes guard and organize the three-
dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can …
dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can …
SMC5/6 complex-mediated SUMOylation stimulates DNA–protein cross-link repair in Arabidopsis
E Dvořák Tomaštíková, K Prochazkova, F Yang… - The Plant …, 2023 - academic.oup.com
DNA–protein cross-links (DPCs) are highly toxic DNA lesions consisting of proteins
covalently attached to chromosomal DNA. Unrepaired DPCs physically block DNA …
covalently attached to chromosomal DNA. Unrepaired DPCs physically block DNA …
The SMC5/6 complex: folding chromosomes back into shape when genomes take a break
S Roy, H Adhikary, D D'Amours - Nucleic Acids Research, 2024 - academic.oup.com
High-level folding of chromatin is a key determinant of the shape and functional state of
chromosomes. During cell division, structural maintenance of chromosome (SMC) …
chromosomes. During cell division, structural maintenance of chromosome (SMC) …
The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
L Mahrík, B Stefanovie, A Maresova, J Princova… - Epigenetics & …, 2023 - Springer
Abstract Background Structural Maintenance of Chromosomes (SMC) complexes are
molecular machines driving chromatin organization at higher levels. In eukaryotes, three …
molecular machines driving chromatin organization at higher levels. In eukaryotes, three …
Best Practices of Using AI-Based Models in Crystallography and Their Impact in Structural Biology
The recent breakthrough made in the field of three-dimensional (3D) structure prediction by
artificial intelligence softwares, such as initially AlphaFold2 (AF2) and RosettaFold (RF) and …
artificial intelligence softwares, such as initially AlphaFold2 (AF2) and RosettaFold (RF) and …