[HTML][HTML] Twisted intramolecular charge transfer (TICT) and twists beyond TICT: from mechanisms to rational designs of bright and sensitive fluorophores
The twisted intramolecular charge transfer (TICT) mechanism has guided the development
of numerous bright and sensitive fluorophores. This review briefly overviews the history of …
of numerous bright and sensitive fluorophores. This review briefly overviews the history of …
Molecular fluorophores for deep-tissue bioimaging
Fluorescence imaging has made tremendous inroads toward understanding the complexity
of biological systems, but in vivo deep-tissue imaging remains a great challenge due to the …
of biological systems, but in vivo deep-tissue imaging remains a great challenge due to the …
[HTML][HTML] A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
The quality and application of super-resolution fluorescence imaging greatly lie in the dyes'
properties, including photostability, brightness, and Stokes shift. Here we report a synergistic …
properties, including photostability, brightness, and Stokes shift. Here we report a synergistic …
An emerging molecular design approach to heavy-atom-free photosensitizers for enhanced photodynamic therapy under hypoxia
A novel strategy for designing highly efficient and activatable photosensitizers that can
effectively generate reactive oxygen species (ROS) under both normoxia and hypoxia is …
effectively generate reactive oxygen species (ROS) under both normoxia and hypoxia is …
[HTML][HTML] Monitoring amyloid aggregation via a twisted intramolecular charge transfer (TICT)-based fluorescent sensor array
Imaging amyloid-beta (Aβ) aggregation is critical for understanding the pathology and aiding
the pre-symptomatic intervention of Alzheimer's disease (AD). Amyloid aggregation consists …
the pre-symptomatic intervention of Alzheimer's disease (AD). Amyloid aggregation consists …
Chemical approaches to optimize the properties of organic fluorophores for imaging and sensing
G Jiang, H Liu, H Liu, G Ke, TB Ren… - Angewandte …, 2024 - Wiley Online Library
Organic fluorophores are indispensable tools in cells, tissue and in vivo imaging, and have
enabled much progress in the wide range of biological and biomedical fields. However …
enabled much progress in the wide range of biological and biomedical fields. However …
Direct quantification and visualization of homocysteine, cysteine, and glutathione in Alzheimer's and Parkinson's disease model tissues
G Yin, Y Gan, H Jiang, T Yu, M Liu, Y Zhang… - Analytical …, 2021 - ACS Publications
Alzheimer's disease (AD) and Parkinson's disease (PD) are chronic neurodegenerative
diseases with high morbidity and mortality. Homocysteine (Hcy), cysteine (Cys), and …
diseases with high morbidity and mortality. Homocysteine (Hcy), cysteine (Cys), and …
The design and bioimaging applications of NIR fluorescent organic dyes with high brightness
J Wu, Z Shi, L Zhu, J Li, X Han, M Xu… - Advanced Optical …, 2022 - Wiley Online Library
Due to the merits of decreased photon attenuation, autofluorescence, and scattering, the
near‐infrared (NIR, 700–1700 nm) region is an important window in the field of biomedicine …
near‐infrared (NIR, 700–1700 nm) region is an important window in the field of biomedicine …
[HTML][HTML] Regulating the proximity effect of heterocycle-containing AIEgens
Proximity effect, which refers to the low-lying (n, π*) and (π, π*) states with close energy
levels, usually plays a negative role in the luminescent behaviors of heterocyclic …
levels, usually plays a negative role in the luminescent behaviors of heterocyclic …
Quantitative design of bright fluorophores and AIEgens by the accurate prediction of twisted intramolecular charge transfer (TICT)
Inhibition of TICT can significantly increase the brightness of fluorescent materials. Accurate
prediction of TICT is thus critical for the quantitative design of high‐performance …
prediction of TICT is thus critical for the quantitative design of high‐performance …