Autologous dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are a
promising immunological tool for cancer therapy. These stimulate the antitumor response …

Dendritic cell (DC)-based immunotherapy employs the patients' immune system to fight
neoplastic lesions spread over the entire body. This makes it an important therapy option for …

Background: Recently, we produced a tumour antigen-presenting cells (TAPCells) vaccine
using a melanoma cell lysate, called TRIMEL, as an antigen source and an activation factor …

Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some
patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance …

Hesperidin methyl chalcone (HMC) is a safe flavonoid used to treat chronic venous
diseases, but its effects and mechanisms on UVB irradiation-induced inflammation and …

The success of cellular immunotherapies against cancer requires the generation of activated
CD4+ and CD8+ T-cells. The type of T-cell response generated (eg, Th1 or Th2) will …

Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-
formed plasma membrane channels that allow for the passage of small molecules between …

As tumors employ complementary overlapping and/or independent mechanisms to evade
immune surveillance, many emerging cancer immunotherapies attempt to target multiple …

Damage-associated molecular patterns (DAMPs) play a critical role in dendritic cells (DCs)
ability to trigger a specific and efficient adaptive immune response for different physiological …

Abstract Background Dendritic cells (DCs) are usually immunogenic, but they are also
capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on …