Natural compounds regulate the PI3K/Akt/GSK3β pathway in myocardial ischemia-reperfusion injury

AH Ajzashokouhi, R Rezaee, N Omidkhoda, G Karimi - Cell Cycle, 2023 - Taylor & Francis
ABSTRACT The PI3K/Akt/GSK3β pathway is crucial in regulating cardiomyocyte growth and
survival. It has been shown that activation of this pathway alleviates the negative impact of …

Ischemia reperfusion injury induced blood brain barrier dysfunction and the involved molecular mechanism

X Guo, R Liu, M Jia, Q Wang, J Wu - Neurochemical Research, 2023 - Springer
Stroke is characterized by the abrupt failure of blood flow to a specific brain region, resulting
in insufficient supply of oxygen and glucose to the ischemic tissues. Timely reperfusion of …

Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola …

N Xing, J Qin, D Ren, Q Du, Y Li, J Mi, F Zhang… - Journal of …, 2023 - Elsevier
Ethnopharmacology relevance Rhodiola granules (RG) is a traditional Tibetan medicine
prescription that can be used to improve the symptoms of ischemia and hypoxia in …

[HTML][HTML] BMSC‑derived exosome‑mediated miR‑25‑3p delivery protects against myocardial ischemia/reperfusion injury by constraining M1‑like macrophage …

J Du, Y Dong, J Song, H Shui… - Molecular …, 2024 - spandidos-publications.com
Myocardial ischemia/reperfusion injury (MIRI) is a significant challenge in the management
of myocardial ischemic disease. Extensive evidence suggests that the macrophage …

[HTML][HTML] Expression Pattern and Molecular Mechanism of Oxidative Stress-Related Genes in Myocardial Ischemia–Reperfusion Injury

J Wu, J Luo, H Cai, C Li, Z Lei, Y Lu, L Ni, J Cao… - Journal of …, 2023 - mdpi.com
(1) Background: The molecular mechanism of oxidative stress-related genes (OSRGs) in
myocardial ischemia–reperfusion injury (MIRI) has not been fully elucidated.(2) Methods …

Blockage of PHLPP1 protects against myocardial ischemia/reperfusion injury in diabetic mice via activation of STAT3 signaling

S Gao, Y Qiu, Y Meng, Y Jia, X Lang, H Zhao… - Journal of Bioenergetics …, 2023 - Springer
Diabetes can exacerbate myocardial ischemia/reperfusion (IR) injury. However, the
sensitivity to IR injury and the underlying mechanisms in diabetic hearts remain unclear …

[HTML][HTML] Lnc-PXMP4-2-4 alleviates myocardial cell damage by activating the JAK2/STAT3 signaling pathway

H Zhang, Q Guo, G Feng, X Shen, X Feng, Y Guo… - Heliyon, 2023 - cell.com
Purpose The aim of this study was to investigate the protective effect of long non-coding lnc-
PXMP4-2-4 on myocardial cell damage caused by acute myocardial infarction (AMI) …

[HTML][HTML] Effects of scutellarin on the mechanism of cardiovascular diseases: a review

X Zhang, T Yin, Y Wang, J Du, J Dou… - Frontiers in …, 2024 - frontiersin.org
Cardiovascular diseases represent a significant worldwide problem, jeopardizing
individuals' physical and mental wellbeing as well as their quality of life as a result of their …

Ursolic acid improves necroptosis via STAT3 signaling in intestinal ischemia/reperfusion injury

Y Shi, J Liu, M Hou, Z Tan, F Chen, J Zhang… - International …, 2024 - Elsevier
Intestinal ischemia/reperfusion injury (IRI) poses a serious threat to human survival and
quality of life with high mortality and morbidity rates. The current absence of effective …

Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway

L Ji, S Lou, Y Fang, X Wang, W Zhu, G Liang, K Lee… - Pharmaceuticals, 2024 - mdpi.com
Diabetic cardiomyopathy (DCM) represents a common pathological state brought about by
diabetes mellitus (DM). Patchouli alcohol (PatA) is known for its diverse advantageous …