Mechanics and functional consequences of nuclear deformations
As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …
fate and function in response to various signals and stimuli. In addition to biochemical …
Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
Y Gruenbaum, R Foisner - Annual review of biochemistry, 2015 - annualreviews.org
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
[HTML][HTML] Force triggers YAP nuclear entry by regulating transport across nuclear pores
YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …
regeneration, and organ size control. Here, we show that force applied to the nucleus …
Squish and squeeze—the nucleus as a physical barrier during migration in confined environments
From embryonic development to cancer metastasis, cell migration plays a central role in
health and disease. It is increasingly becoming apparent that cells migrating in three …
health and disease. It is increasingly becoming apparent that cells migrating in three …
[HTML][HTML] Nuclear lamins: Structure and function in mechanobiology
Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …
The neutrophil nucleus: an important influence on neutrophil migration and function
HR Manley, MC Keightley, GJ Lieschke - Frontiers in immunology, 2018 - frontiersin.org
Neutrophil nuclear morphology has historically been used in haematology for neutrophil
identification and characterisation, but its exact role in neutrophil function has remained …
identification and characterisation, but its exact role in neutrophil function has remained …
A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)
E Giorgio, D Robyr, M Spielmann… - Human molecular …, 2015 - academic.oup.com
Chromosomal rearrangements with duplication of the lamin B1 (LMNB1) gene underlie
autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare neurological …
autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare neurological …
Bursting the bubble–nuclear envelope rupture as a path to genomic instability?
The nuclear envelope safeguards the genetic material inside the nucleus by separating it
from the cytoplasm. Until recently, it was assumed that nuclear envelope (NE) breakdown …
from the cytoplasm. Until recently, it was assumed that nuclear envelope (NE) breakdown …
Causes and consequences of nuclear envelope alterations in tumour progression
ES Bell, J Lammerding - European journal of cell biology, 2016 - Elsevier
Morphological changes in the size and shape of the nucleus are highly prevalent in cancer,
but the underlying molecular mechanisms and the functional relevance remain poorly …
but the underlying molecular mechanisms and the functional relevance remain poorly …
Cellular geometry sensing at different length scales and its implications for scaffold design
M Werner, NA Kurniawan, CVC Bouten - Materials, 2020 - mdpi.com
Geometrical cues provided by the intrinsic architecture of tissues and implanted biomaterials
have a high relevance in controlling cellular behavior. Knowledge of how cells sense and …
have a high relevance in controlling cellular behavior. Knowledge of how cells sense and …