Social isolation and cognitive function in later life: a systematic review and meta-analysis
IEM Evans, A Martyr, R Collins… - Journal of Alzheimer's …, 2019 - content.iospress.com
Background: There is some evidence to suggest that social isolation may be associated with
poor cognitive function in later life. However, findings are inconsistent and there is wide …
poor cognitive function in later life. However, findings are inconsistent and there is wide …
Brain age and other bodily 'ages': implications for neuropsychiatry
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …
with many important life outcomes. We combine cognitive and genetic data from the …
Brain age predicts mortality
Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …
Epigenetic signatures of cigarette smoking
Background—DNA methylation leaves a long-term signature of smoking exposure and is
one potential mechanism by which tobacco exposure predisposes to adverse health …
one potential mechanism by which tobacco exposure predisposes to adverse health …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders
S Ligthart, A Vaez, U Võsa, MG Stathopoulou… - The American Journal of …, 2018 - cell.com
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic …
associated with multiple complex diseases. The genetic determinants of chronic …
DNA methylation age of blood predicts all-cause mortality in later life
Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
Background: The DNA methylation-based 'epigenetic clock'correlates strongly with
chronological age, but it is currently unclear what drives individual differences. We examine …
chronological age, but it is currently unclear what drives individual differences. We examine …