Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Interplay between inflammation and thrombosis in cardiovascular pathology

K Stark, S Massberg - Nature Reviews Cardiology, 2021 - nature.com
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …

[HTML][HTML] Effects of COVID-19 on the nervous system

C Iadecola, J Anrather, H Kamel - Cell, 2020 - cell.com
Neurological complications have emerged as a significant cause of morbidity and mortality
in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized …

Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

Stroke risk factors, genetics, and prevention

AK Boehme, C Esenwa, MSV Elkind - Circulation research, 2017 - Am Heart Assoc
Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends
on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as …

Acute infection and myocardial infarction

DM Musher, MS Abers… - New England Journal of …, 2019 - Mass Medical Soc
Risk of MI after Acute Infection Among patients who are hospitalized for pneumococcal
pneumonia, the incidence of myocardial infarction is 7 to 8%. The true incidence of …

Cardioembolic stroke

H Kamel, JS Healey - Circulation research, 2017 - Am Heart Assoc
Cardiac embolism accounts for an increasing proportion of ischemic strokes and might
multiply several-fold during the next decades. However, research points to several potential …

Thromboinflammation: from atherosclerosis to COVID-19

DD Wagner, LA Heger - Arteriosclerosis, thrombosis, and vascular …, 2022 - Am Heart Assoc
The activating interplay of thrombosis and inflammation (thromboinflammation) has been
established as a major underlying pathway, driving not only cardiovascular disease but also …

Understanding infection-induced thrombosis: lessons learned from animal models

N Beristain-Covarrubias, M Perez-Toledo… - Frontiers in …, 2019 - frontiersin.org
Thrombosis is a common consequence of infection that is associated with poor patient
outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is …

The dormant blood microbiome in chronic, inflammatory diseases

M Potgieter, J Bester, DB Kell… - FEMS microbiology …, 2015 - academic.oup.com
Blood in healthy organisms is seen as a 'sterile'environment: it lacks proliferating microbes.
Dormant or not-immediately-culturable forms are not absent, however, as intracellular …