Trends in the development of miRNA bioinformatics tools

L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …

Rep‐Seq: uncovering the immunological repertoire through next‐generation sequencing

J Benichou, R Ben‐Hamo, Y Louzoun, S Efroni - Immunology, 2012 - Wiley Online Library
Recent scientific discoveries fuelled by the application of next‐generation DNA and RNA
sequencing technologies highlight the striking impact of these platforms in characterizing …

Predicting effective microRNA target sites in mammalian mRNAs

V Agarwal, GW Bell, JW Nam, DP Bartel - elife, 2015 - elifesciences.org
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …

Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells

ML Squadrito, C Baer, F Burdet, C Maderna… - Cell reports, 2014 - cell.com
MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication.
Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion …

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

JE Squires, HR Patel, M Nousch, T Sibbritt… - Nucleic acids …, 2012 - academic.oup.com
The modified base 5-methylcytosine (m 5 C) is well studied in DNA, but investigations of its
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …

Functional microRNA targets in protein coding sequences

M Reczko, M Maragkakis, P Alexiou, I Grosse… - …, 2012 - academic.oup.com
Motivation: Experimental evidence has accumulated showing that microRNA (miRNA)
binding sites within protein coding sequences (CDSs) are functional in controlling gene …

MiRmap: comprehensive prediction of microRNA target repression strength

CE Vejnar, EM Zdobnov - Nucleic acids research, 2012 - academic.oup.com
MicroRNAs, or miRNAs, post-transcriptionally repress the expression of protein-coding
genes. The human genome encodes over 1000 miRNA genes that collectively target the …

GDNF overexpression from the native locus reveals its role in the nigrostriatal dopaminergic system function

A Kumar, J Kopra, K Varendi, LL Porokuokka… - PLoS …, 2015 - journals.plos.org
Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's
disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of …

MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells

LH Gregersen, A Jacobsen, LB Frankel, J Wen… - BMC cancer, 2012 - Springer
Background MicroRNAs (miRNAs) are well recognized as gene regulators and have been
implicated in the regulation of development as well as human diseases. miR-143 is located …

[HTML][HTML] Determinants of functional microRNA targeting

H Hwang, HR Chang, D Baek - Molecules and cells, 2023 - Elsevier
MicroRNAs (miRNAs) play cardinal roles in regulating biological pathways and processes,
resulting in significant physiological effects. To understand the complex regulatory network …