Trends in the development of miRNA bioinformatics tools
L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …
recognition of cognate sequences and interference of transcriptional, translational or …
Rep‐Seq: uncovering the immunological repertoire through next‐generation sequencing
Recent scientific discoveries fuelled by the application of next‐generation DNA and RNA
sequencing technologies highlight the striking impact of these platforms in characterizing …
sequencing technologies highlight the striking impact of these platforms in characterizing …
Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …
and complementary sites within target mRNAs, but not all of these canonical sites are …
Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells
ML Squadrito, C Baer, F Burdet, C Maderna… - Cell reports, 2014 - cell.com
MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication.
Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion …
Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion …
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
JE Squires, HR Patel, M Nousch, T Sibbritt… - Nucleic acids …, 2012 - academic.oup.com
The modified base 5-methylcytosine (m 5 C) is well studied in DNA, but investigations of its
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
Functional microRNA targets in protein coding sequences
Motivation: Experimental evidence has accumulated showing that microRNA (miRNA)
binding sites within protein coding sequences (CDSs) are functional in controlling gene …
binding sites within protein coding sequences (CDSs) are functional in controlling gene …
MiRmap: comprehensive prediction of microRNA target repression strength
CE Vejnar, EM Zdobnov - Nucleic acids research, 2012 - academic.oup.com
MicroRNAs, or miRNAs, post-transcriptionally repress the expression of protein-coding
genes. The human genome encodes over 1000 miRNA genes that collectively target the …
genes. The human genome encodes over 1000 miRNA genes that collectively target the …
GDNF overexpression from the native locus reveals its role in the nigrostriatal dopaminergic system function
Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's
disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of …
disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of …
MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells
Background MicroRNAs (miRNAs) are well recognized as gene regulators and have been
implicated in the regulation of development as well as human diseases. miR-143 is located …
implicated in the regulation of development as well as human diseases. miR-143 is located …
[HTML][HTML] Determinants of functional microRNA targeting
H Hwang, HR Chang, D Baek - Molecules and cells, 2023 - Elsevier
MicroRNAs (miRNAs) play cardinal roles in regulating biological pathways and processes,
resulting in significant physiological effects. To understand the complex regulatory network …
resulting in significant physiological effects. To understand the complex regulatory network …