It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

A doença de Alzheimer é a patologia neurodegenerativa mais freqüente associada à idade,
cujas manifestações cognitivas e neuropsiquiátricas resultam em deficiência progressiva e …

Alzheimer's disease (AD) is a disabling and highly prevalent neurodegenerative condition,
for which there are no effective therapies. Soluble oligomers of the amyloid-β peptide (AβOs) …

Alzheimer disease is characterized by the abnormal aggregation of amyloid β peptide into
extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been …

In the sanctity of pure drug discovery, objective reasoning can become clouded when
pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into …

Alzheimer's disease (AD) and several other neurological disorders have been linked to the
overactivation of glutamatergic transmission and exci‐totoxicity as a common pathway of …

We report that fullerene inhibits strongly the amyloid peptide aggregation at the early stage.
It specifically binds to the central hydrophobic motif, KLVFF, of Aβ peptides. The IC50 value …

Amyloid plaques are hallmark neuropathological lesions in Alzheimer's disease, which
consist of abnormally aggregated Aβ protein. Multiple Aβ aggregated species have been …

Genetic, neuropathological, and biochemical studies have provided strong evidence for a
central role of amyloid in the pathogenesis of Alzheimer's disease (AD). We have proposed …

We present the first electrochemical detection, characterization, and kinetic study of the
aggregation of Alzheimer's disease (AD) amyloid beta peptides (Aβ-40, Aβ-42) using three …